L. Stefan Lohmander

TL;DR: A whole joint scoring system incorporating acute structural tissue damage and longitudinal changes including osteoarthritis features that may be relevant for structural outcome not covered by established OA scoring instruments is developed.

TL;DR: In this article, the authors identified and defined symptomatic early-stage OA of the knee (the focus of this review) urgently needs to be identified, as efficient early stage case finding and diagnosis in primary care would enable health care providers to proactively and substantially reduce the burden of disease through proper management including structured education, exercise and weight management (when needed) and addressing lifestyle-related risk factors for disease progression.

TL;DR: In this paper, the authors evaluated the effectiveness of oral glucosamine in subgroups of people with hip or knee osteoarthritis based on baseline pain severity, body mass index (BMI), sex, structural abnormalities and presence of inflammation using individual patient data.

TL;DR: Patients declining to participate in the RCT were more frequently self-employed and less frequently injured in sports activities than those accepting RCT participation, and the a priori sample size calculation needs to be multiplied by at least 5.5 to provide an estimate of the number needed to screen and allocate.

TL;DR: The genetics of osteoarthritis are clarified, those at risk for progression and severe disease are identified, and molecular processes critical for joint survival and failure are identified.