F
Frank P. Luyten
Researcher at Katholieke Universiteit Leuven
Publications - 397
Citations - 25993
Frank P. Luyten is an academic researcher from Katholieke Universiteit Leuven. The author has contributed to research in topics: Bone morphogenetic protein & Cartilage. The author has an hindex of 81, co-authored 386 publications receiving 23736 citations. Previous affiliations of Frank P. Luyten include Flanders Institute for Biotechnology & National Institutes of Health.
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Multipotent mesenchymal stem cells from adult human synovial membrane
TL;DR: It is demonstrated that human multipotent MSCs can be isolated from the SM of knee joints and have the ability to proliferate extensively in culture, and they maintain their multilineage differentiation potential in vitro, establishing their progenitor cell nature.
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Identification of multiple active growth factors in basement membrane matrigel suggests caution in interpretation of cellular activity related to extracellular matrix components
Slobodan Vukicevic,Hynda K. Kleinman,Frank P. Luyten,Anita B. Roberts,Nanette S. Roche,A. H. Reddi +5 more
TL;DR: It is demonstrated that reconstituted basement membrane contains growth factors which influence cellular behavior, suggesting caution in the interpretation of experiments on cellular activity related to Matrigel, collagen type IV, and possibly other extracellular matrix components.
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Characterized Chondrocyte Implantation Results in Better Structural Repair When Treating Symptomatic Cartilage Defects of the Knee in a Randomized Controlled Trial Versus Microfracture
Daniel B.F. Saris,Johan Vanlauwe,Jan Victor,Miroslav Hašpl,Michael Bohnsack,Yves Fortems,Bruno Vandekerckhove,K. Frederik Almqvist,Toon Claes,F. Handelberg,Koen Lagae,Jan Van Der Bauwhede,Hilde Vandenneucker,K. Gie Auw Yang,Mislav Jelić,René Verdonk,Nancy Veulemans,Johan Bellemans,Frank P. Luyten +18 more
TL;DR: One year after treatment, characterized chondrocyte implantation was associated with a tissue regenerate that was superior to that after microfracture, and the superior structural outcome may result in improved long-term clinical benefit with characterized chontological implantation.
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Frzb, a Secreted Protein Expressed in the Spemann Organizer, Binds and Inhibits Wnt-8
TL;DR: Observations implicate Frzb in axial patterning and support the concept that Frzb binds and inactivates Xwnt-8 during gastrulation, preventing inappropriate ventral signaling in developing dorsal tissues.
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The bone–cartilage unit in osteoarthritis
Rik Lories,Frank P. Luyten +1 more
TL;DR: Several molecular signaling pathways such as bone morphogenetic proteins and Wnts are hypothesized to have a role in OA and can activate cellular and molecular processes in both cartilage and bone cells, which could lead to the development of specific therapeutics or treatment strategies.