Ladislav Janský

TL;DR: The hypothesis that physiological changes induced by water immersion are mediated by humoral control mechanisms, while responses induced by cold are mainly due to increased activity of the sympathetic nervous system is supported.

TL;DR: Changes in concentrations of cytokines in plasma and in hypothalamic push-pull perfusates of guinea pigs were measured within the 1st hour after intramuscular injections of bacterial lipopolysaccharide or solvent and the method used did not detect any changes in the amount of biologically active IL-1 in hypothalamusates of LPS-treated animals.

TL;DR: It was concluded that the stress-inducing noninfectious stimuli, such as repeated cold water immersions, which increased metabolic rate due to shivering the elevated blood concentrations of catecholamines, activated the immune system to a slight extent.

TL;DR: Saturation studies on crude membrane fraction revealed high-affinity melatonin binding sites in median eminence and anterior pituitary in hamsters maintained on LD 14:10 and long-term exposure to LD 8:16 decreased the concentration to less than a half.

TL;DR: Evidence is provided that endogenous antipyretics cancel changes in neuronal activities which have been induced by endogenous pyrogens such as cytokines and prostaglandins, which is compatible with a limitation of fever in strength and duration.