L
Lalitha Iyer
Researcher at University of Chicago
Publications - 24
Citations - 3497
Lalitha Iyer is an academic researcher from University of Chicago. The author has contributed to research in topics: Glucuronidation & Irinotecan. The author has an hindex of 16, co-authored 24 publications receiving 3381 citations. Previous affiliations of Lalitha Iyer include Boston Children's Hospital.
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Journal ArticleDOI
Genetic variants in the UDP-glucuronosyltransferase 1A1 gene predict the risk of severe neutropenia of irinotecan.
Federico Innocenti,Samir D. Undevia,Lalitha Iyer,Peixian Chen,Soma Das,Masha Kocherginsky,Theodore Karrison,Linda Janisch,Jacqueline Ramírez,Charles M. Rudin,Everett E. Vokes,Mark J. Ratain +11 more
TL;DR: UGT1A1 genotype and total bilirubin levels are strongly associated with severe neutropenia, and could be used to identify cancer patients predisposed to the severe toxicity of irinotecan.
Journal ArticleDOI
UGT1A1*28 polymorphism as a determinant of irinotecan disposition and toxicity
Lalitha Iyer,Soma Das,Linda Janisch,Ming Wen,Jacqueline Ramírez,Theodore Karrison,Gini F. Fleming,Everett E. Vokes,Richard L. Schilsky,Mark J. Ratain +9 more
TL;DR: It is suggested that screening for UGT1A1*28 polymorphism may identify patients with lower SN-38 glucuronidation rates and greater susceptibility to irinotecan induced gastrointestinal and bone marrow toxicity.
Journal ArticleDOI
Genetic predisposition to the metabolism of irinotecan (CPT-11). Role of uridine diphosphate glucuronosyltransferase isoform 1A1 in the glucuronidation of its active metabolite (SN-38) in human liver microsomes.
Lalitha Iyer,Christopher D. King,Peter F. Whitington,Mitchell D. Green,S K Roy,Thomas R. Tephly,Birgit L. Coffman,Mark J. Ratain +7 more
TL;DR: Findings indicate a genetic predisposition to the metabolism of irinotecan, suggesting that patients with low UGT1A1 activity, such as those with Gilbert's syndrome, may be at an increased risk for irinOTecan toxicity.
Journal ArticleDOI
Phenotype-genotype correlation of in vitro SN-38 (active metabolite of irinotecan) and bilirubin glucuronidation in human liver tissue with UGT1A1 promoter polymorphism
Lalitha Iyer,Diana Hall,Soma Das,Melissa A. Mortell,Jacqueline Ramírez,Sarang Kim,Anna Di Rienzo,Mark J. Ratain +7 more
TL;DR: The presence of an additional TA repeat [(TA)7 TAA] in the TATA sequence of UGT1A1 has been associated with Gilbert's syndrome.
Journal Article
Epirubicin glucuronidation is catalyzed by human UDP-glucuronosyltransferase 2B7
TL;DR: The reported tyrosine to histidine polymorphism in UGT2B7 does not alter the formation rate of epirubicin glucuronide, and undiscovered genetic polymorphisms in U GT2 B7 might change the metabolic fate of this important anticancer agent.