P
Peixian Chen
Researcher at University of Chicago
Publications - 31
Citations - 2546
Peixian Chen is an academic researcher from University of Chicago. The author has contributed to research in topics: Gene & Single-nucleotide polymorphism. The author has an hindex of 19, co-authored 29 publications receiving 2426 citations. Previous affiliations of Peixian Chen include St. Jude Children's Research Hospital & Roswell Park Cancer Institute.
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Journal ArticleDOI
Genetic variants in the UDP-glucuronosyltransferase 1A1 gene predict the risk of severe neutropenia of irinotecan.
Federico Innocenti,Samir D. Undevia,Lalitha Iyer,Peixian Chen,Soma Das,Masha Kocherginsky,Theodore Karrison,Linda Janisch,Jacqueline Ramírez,Charles M. Rudin,Everett E. Vokes,Mark J. Ratain +11 more
TL;DR: UGT1A1 genotype and total bilirubin levels are strongly associated with severe neutropenia, and could be used to identify cancer patients predisposed to the severe toxicity of irinotecan.
Journal ArticleDOI
Comprehensive Pharmacogenetic Analysis of Irinotecan Neutropenia and Pharmacokinetics
Federico Innocenti,Deanna L. Kroetz,Erin G. Schuetz,M. Eileen Dolan,Jacqueline Ramírez,Mary V. Relling,Peixian Chen,Soma Das,Gary L. Rosner,Mark J. Ratain +9 more
TL;DR: Common polymorphisms in genes encoding for ABC and SLC transporters may have a significant impact on the pharmacokinetics and pharmacodynamics of CPT-11.
Journal ArticleDOI
Pharmacogenomic and Pharmacokinetic Determinants of Erlotinib Toxicity
Charles M. Rudin,Wanqing Liu,Apurva A. Desai,Theodore Karrison,Xuemin Jiang,Linda Janisch,Soma Das,Jacqueline Ramírez,Balasubramanian Poonkuzhali,Erin Schuetz,Donna Lee Fackenthal,Peixian Chen,Deborah K. Armstrong,Julie R. Brahmer,Gini F. Fleming,Everett E. Vokes,Michael A. Carducci,Mark J. Ratain +17 more
TL;DR: A combined pharmacogenomic and pharmacokinetic model helps to define and differentiate the primary determinants of skin and gastrointestinal toxicity of erlotinib.
Journal Article
Interethnic Difference in the Allelic Distribution of Human Epidermal Growth Factor Receptor Intron 1 Polymorphism
TL;DR: Major interethnic differences in the allelic frequencies of the EGFR intron 1 polymorphism exist and may contribute to a better understanding of the molecular basis underlying ethnic differences in drug response and may be helpful for future strategies of individualized therapy with EGFR inhibitors.
Journal ArticleDOI
Effects of prednisone and genetic polymorphisms on etoposide disposition in children with acute lymphoblastic leukemia
Shinji Kishi,Wenjian Yang,Wenjian Yang,Wenjian Yang,Benoit Boureau,Benoit Boureau,Benoit Boureau,Stanislas Morand,Stanislas Morand,Stanislas Morand,Soma Das,Soma Das,Soma Das,Peixian Chen,Peixian Chen,Peixian Chen,Edwin H. Cook,Edwin H. Cook,Edwin H. Cook,Gary L. Rosner,Gary L. Rosner,Gary L. Rosner,Erin G. Schuetz,Erin G. Schuetz,Erin G. Schuetz,Ching-Hon Pui,Ching-Hon Pui,Ching-Hon Pui,Mary V. Relling,Mary V. Relling,Mary V. Relling +30 more
TL;DR: Prednisone strongly induces etoposide clearance, genetic polymorphisms may predict the constitutive and induced clearance of etopOSide, and the relationship between genotype and phenotype differs by race.