L
Lanxi Song
Researcher at University of South Florida
Publications - 21
Citations - 4294
Lanxi Song is an academic researcher from University of South Florida. The author has contributed to research in topics: Epidermal growth factor receptor & Lung cancer. The author has an hindex of 18, co-authored 21 publications receiving 4034 citations.
Papers
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Journal ArticleDOI
Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis
Guilian Niu,Kenneth L. Wright,Mei Huang,Lanxi Song,Eric B. Haura,James Turkson,Shumin M. Zhang,Tianhong Wang,Dominic Sinibaldi,Domenico Coppola,Richard Heller,Lee M. Ellis,James G. Karras,Jacqueline Bromberg,Drew M. Pardoll,Richard Jove,Hua Yu +16 more
TL;DR: It is shown that VEGF expression correlates with Stat3 activity in diverse human cancer cell lines and indicates that Stat3 represents a common molecular target for blocking angiogenesis induced by multiple signaling pathways in human cancers.
Journal ArticleDOI
Src kinases as therapeutic targets for cancer
TL;DR: Small-molecule SFK inhibitors have been developed and are undergoing early phase clinical testing and seem to be safe in humans and could add to the therapeutic arsenal against subsets of cancers.
Journal ArticleDOI
Stat3 regulates genes common to both wound healing and cancer
Daniel J Dauer,Bernadette Ferraro,Lanxi Song,Bin Yu,Linda B. Mora,Ralf Buettner,Steve Enkemann,Richard Jove,Eric B. Haura +8 more
TL;DR: Previously uncharacterized genes induced by Stat3 implicated in signaling pathways common to both wound healing and cancer including cell invasion and migration, angiogenesis, modulation of coagulation, and repression of interferon-inducible genes are reported.
Journal ArticleDOI
Activation of Stat3 by receptor tyrosine kinases and cytokines regulates survival in human non-small cell carcinoma cells.
TL;DR: A role of Stat3 is demonstrated in transducing survival signals downstream of tyrosine kinases such as Src, EGF-R, and c-Met, as well as cytokines such as IL-6, in human nonsmall cell lung cancers.
Journal ArticleDOI
A chemical and phosphoproteomic characterization of dasatinib action in lung cancer.
Jiannong Li,Uwe Rix,Bin Fang,Yun Bai,Arthur Edwards,Jacques Colinge,Keiryn L. Bennett,Jingchun Gao,Lanxi Song,Steven A. Eschrich,Giulio Superti-Furga,John M. Koomen,Eric B. Haura +12 more
TL;DR: The combined mass spectrometry based approach described here provides a system-level view of dasatinib action in cancer cells and suggests both functional targets and rationale combinatorial therapeutic strategies.