Mei Huang

TL;DR: It is shown that VEGF expression correlates with Stat3 activity in diverse human cancer cell lines and indicates that Stat3 represents a common molecular target for blocking angiogenesis induced by multiple signaling pathways in human cancers.

TL;DR: The findings suggest that activated Stat3 signaling contributes to breast cancer progression and resistance to chemotherapy by, at least in part, inducing expression of the antiapoptotic protein, Survivin.

TL;DR: This study investigates the effect of tumor-derived factors on Janus kinase (Jak)/STAT signaling in myeloid cells during their differentiation into dendritic cells and demonstrates that tumor- derived factors may affect myeloids cell differentiation in cancer via constitutive activation of Jak2/STAT3.

TL;DR: It is demonstrated that Stat3 is constitutively activated in a majority of human melanoma cell lines and tumor specimens examined and that Src-activated Stat3 signaling is important for the growth and survival of melanoma tumor cells.

TL;DR: It is shown that Stat3 signaling plays a critical role in the induction of antigen-specific T cell tolerance, and provides a novel molecular target for manipulation of immune activation/tolerance, a central decision with profound implications in autoimmunity, transplantation, and cancer immunotherapy.