R
Richard Jove
Researcher at University of South Florida
Publications - 155
Citations - 27841
Richard Jove is an academic researcher from University of South Florida. The author has contributed to research in topics: Proto-oncogene tyrosine-protein kinase Src & STAT3. The author has an hindex of 77, co-authored 155 publications receiving 26422 citations.
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Journal ArticleDOI
Constitutive Activation of Stat3 Signaling Confers Resistance to Apoptosis in Human U266 Myeloma Cells
Robyn Catlett-Falcone,Terry H. Landowski,Marc M. Oshiro,James Turkson,Alexander Levitzki,Rocco Savino,Gennaro Ciliberto,Lynn C. Moscinski,Jose L. Fernandez-Luna,Gabriel Núñez,William S. Dalton,Richard Jove +11 more
TL;DR: Findings provide evidence that constitutively activated Stat3 signaling contributes to the pathogenesis of multiple myeloma by preventing apoptosis.
Journal ArticleDOI
Revisiting STAT3 signalling in cancer: new and unexpected biological functions
TL;DR: Well known for its role in tumour cell proliferation, survival, invasion and immunosuppression, JAK–STAT3 signalling also promotes cancer through inflammation, obesity, stem cells and the pre-metastatic niche.
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Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis
Guilian Niu,Kenneth L. Wright,Mei Huang,Lanxi Song,Eric B. Haura,James Turkson,Shumin M. Zhang,Tianhong Wang,Dominic Sinibaldi,Domenico Coppola,Richard Heller,Lee M. Ellis,James G. Karras,Jacqueline Bromberg,Drew M. Pardoll,Richard Jove,Hua Yu +16 more
TL;DR: It is shown that VEGF expression correlates with Stat3 activity in diverse human cancer cell lines and indicates that Stat3 represents a common molecular target for blocking angiogenesis induced by multiple signaling pathways in human cancers.
Journal ArticleDOI
Regulation of the innate and adaptive immune responses by Stat-3 signaling in tumor cells.
Tianhong Wang,Guilian Niu,Marcin Kortylewski,Lyudmila Burdelya,Kenneth H. Shain,Shumin M. Zhang,Raka Bhattacharya,Dmitry I. Gabrilovich,Richard Heller,Domenico Coppola,William S. Dalton,Richard Jove,Drew M. Pardoll,Hua Yu +13 more
TL;DR: It is proposed that tumor Stat-3 activity can mediate immune evasion by blocking both the production and sensing of inflammatory signals by multiple components of the immune system.
Journal Article
Activated STAT Signaling in Human Tumors Provides Novel Molecular Targets for Therapeutic Intervention
TL;DR: Inhibition of constitutively active STAT signaling pathways has been shown repeatedly to inhibit tumor cell growth in vitro and in vivo and provides a novel means for therapeutic intervention in human cancer.