L
Larry C. Ackerson
Researcher at Semel Institute for Neuroscience and Human Behavior
Publications - 20
Citations - 2464
Larry C. Ackerson is an academic researcher from Semel Institute for Neuroscience and Human Behavior. The author has contributed to research in topics: Dopamine & Dopaminergic. The author has an hindex of 18, co-authored 20 publications receiving 2262 citations. Previous affiliations of Larry C. Ackerson include University of California, Los Angeles.
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Journal ArticleDOI
Parkin-deficient Mice Exhibit Nigrostriatal Deficits but Not Loss of Dopaminergic Neurons
Matthew S. Goldberg,Sheila M. Fleming,James Palacino,Carlos Cepeda,Hoa A. Lam,Anushree Bhatnagar,Edward G. Meloni,Nanping Wu,Larry C. Ackerson,Gloria J. Klapstein,Mahadevan Gajendiran,Bryan L. Roth,Marie-Françoise Chesselet,Nigel T. Maidment,Michael Levine,Jie Shen +15 more
TL;DR: A mouse model bearing a germline disruption in parkin is generated, providing the first evidence for a novel role of parkin in dopamine regulation and nigrostriatal function, and a non-essential role in the survival of nigral neurons in mice.
Journal ArticleDOI
Cerebral microdialysis combined with single-neuron and electroencephalographic recording in neurosurgical patients. Technical note.
Itzhak Fried,Charles L. Wilson,Nigel T. Maidment,Jerome Engel,Eric Behnke,Tony A. Fields,Katherine A. Macdonald,Jack W. Morrow,Larry C. Ackerson +8 more
TL;DR: A technique is described for measuring extracellular neurochemicals by cerebral microdialysis with simultaneous recording of electroencephalographic (EEG) and single-unit (neuron) activity in selected targets in the human brain.
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Bacterial Artificial Chromosome Transgenic Mice Expressing a Truncated Mutant Parkin Exhibit Age-Dependent Hypokinetic Motor Deficits, Dopaminergic Neuron Degeneration, and Accumulation of Proteinase K-Resistant α-Synuclein
Xiao-Hong Lu,Sheila M. Fleming,Bernhard H. Meurers,Larry C. Ackerson,Farzad Mortazavi,Victor Lo,Daniela Hernandez,David Sulzer,George R. Jackson,Nigel T. Maidment,Marie-Françoise Chesselet,X. William Yang +11 more
TL;DR: This study provides the first mammalian genetic evidence that dominant toxicity of a parkin mutant is sufficient to elicit age-dependent hypokinetic motor deficits and DA neuron loss in vivo, and uncovers a causal relationship between dominant parkin toxicity and progressive α-synuclein accumulation in DA neurons.
Journal ArticleDOI
Comparison of seizure related amino acid release in human epileptic hippocampus versus a chronic, kainate rat model of hippocampal epilepsy
Charles L. Wilson,Nigel T. Maidment,Marc H. Shomer,Eric Behnke,Larry C. Ackerson,Itzhak Fried,Jerome Engel +6 more
TL;DR: The chronic rat model shows increases in the same amino acids as in the human epileptic hippocampus, both during spontaneous seizures and stimulation evoked after-discharges (ADs), which correlate with the degree of mossy fiber reorganization found in the dentate gyrus of kainate rats or epileptic humans.
Journal ArticleDOI
Elevated Tonic Extracellular Dopamine Concentration and Altered Dopamine Modulation of Synaptic Activity Precede Dopamine Loss in the Striatum of Mice Overexpressing Human α-Synuclein
Hoa A. Lam,Nanping Wu,Ingrid Cely,Ingrid Cely,Rachel L. Kelly,Rachel L. Kelly,Sindalana Hean,Franziska Richter,Iddo Magen,Carlos Cepeda,Larry C. Ackerson,Larry C. Ackerson,Wendy Walwyn,Eliezer Masliah,Marie-Françoise Chesselet,Michael Levine,Nigel T. Maidment +16 more
TL;DR: Observations indicate that overexpression of α‐Syn alters dopamine efflux and D2 receptor modulation of corticostriatal glutamate release at a young age and provides evidence for early dopamine synaptic dysfunction prior to loss of striatal dopamine.