Lars Grotewold

TL;DR: By genetic deletion, it is shown that, although they are prone to differentiate, embryonic stem cells can self-renew indefinitely in the permanent absence of Nanog, and it is surmised that Nanog stabilizes embryonicstem cells in culture by resisting or reversing alternative gene expression states.

TL;DR: It is shown that Oct4 and Stat3 intersect in directing expression of Klf transcriptional regulators with overlapping properties that additively reinforce ground-state ESC pluripotency, identity, and self-renewal.

TL;DR: It is speculated that the self-renewing NS cell state may be generated in vitro following transcriptional resetting induced by FGF, and a set of markers expressed by mouse NS cells but not ES cells are identified.

TL;DR: A crucial role is established for BRE in the regulation of key proteins of the cellular stress‐response machinery and an explanation for the multifunctional nature of BRE is provided.

TL;DR: This study identifies two new players in interdigital cell death and highlights that PCD is regulated by a delicate balance of proapoptotic and survival‐promoting activities.