S
Sze Wan Shan
Researcher at Hong Kong Polytechnic University
Publications - 30
Citations - 928
Sze Wan Shan is an academic researcher from Hong Kong Polytechnic University. The author has contributed to research in topics: Trabecular meshwork & microRNA. The author has an hindex of 14, co-authored 27 publications receiving 832 citations. Previous affiliations of Sze Wan Shan include Sunnybrook Health Sciences Centre & The Chinese University of Hong Kong.
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Journal ArticleDOI
MicroRNA MiR-17 retards tissue growth and represses fibronectin expression
Sze Wan Shan,Daniel Y. Lee,Daniel Y. Lee,Zhaoqun Deng,Tatiana Shatseva,Zina Jeyapalan,Zina Jeyapalan,William W. Du,Yaou Zhang,Jim W. Xuan,Siu-Pok Yee,Siu-Pok Yee,Vinayakumar Siragam,Burton B. Yang,Burton B. Yang +14 more
TL;DR: It is shown that overexpression of miR-17 results in decreased cell adhesion, migration and proliferation, and the single miRNA expression assay may be evolved to allow the manipulation of individual miRNA functions in vitro and in vivo.
Journal ArticleDOI
Mature miR-17-5p and passenger miR-17-3p induce hepatocellular carcinoma by targeting PTEN, GalNT7 and vimentin in different signal pathways
Sze Wan Shan,Sze Wan Shan,Ling Fang,Ling Fang,Tatiana Shatseva,Tatiana Shatseva,Zina Jeyapalan Rutnam,Zina Jeyapalan Rutnam,Xiangling Yang,Xiangling Yang,William W. Du,William W. Du,Wei-Yang Lu,Jim W. Xuan,Zhaoqun Deng,Zhaoqun Deng,Burton B. Yang,Burton B. Yang +17 more
TL;DR: It is demonstrated that a mature miRNA can function synergistically with its passenger strand leading to the same phenotype but by regulating different targets located in different signaling pathways.
Journal ArticleDOI
MicroRNA miR-24 enhances tumor invasion and metastasis by targeting PTPN9 and PTPRF to promote EGF signaling
William W. Du,Ling Fang,Ling Fang,Minhui Li,Minhui Li,Minhui Li,Xiangling Yang,Xiangling Yang,Yaoyun Liang,Chun Peng,Chun Peng,Wei Qian,Yunxia O'Malley,Ryan W. Askeland,Sonia L. Sugg,Jun Qian,Jiang Lin,Zide Jiang,Albert Yee,Michael Sefton,Zhaoqun Deng,Zhaoqun Deng,Sze Wan Shan,Sze Wan Shan,Chia Hui Wang,Chia Hui Wang,Burton B. Yang,Burton B. Yang +27 more
TL;DR: The results suggest that miR-24 plays a key role in breast cancer invasion and metastasis and could potentially be a target for cancer intervention.
Journal ArticleDOI
Versican G3 promotes mouse mammary tumor cell growth, migration, and metastasis by influencing EGF receptor signaling.
William W. Du,William W. Du,Burton B. Yang,Tatiana Shatseva,Bing L. Yang,Bing L. Yang,Zhaoqun Deng,Sze Wan Shan,Daniel Y. Lee,Arun Seth,Albert Yee +10 more
TL;DR: Experiments in a syngeneic orthotopic animal model demonstrated that G3 promoted tumor growth and systemic metastasis in vivo, and EGFR-signaling appears to be an important pathway in versican G3-mediated breast cancer tumor invasiveness and metastasis.
Journal ArticleDOI
The intermediate filament vimentin mediates microRNA miR-378 function in cellular self-renewal by regulating the expression of the Sox2 transcription factor.
Zhaoqun Deng,Zhaoqun Deng,William W. Du,William W. Du,Ling Fang,Ling Fang,Sze Wan Shan,Sze Wan Shan,Jun Qian,Jiang Lin,Wei Qian,Ji-chun Ma,Zina Jeyapalan Rutnam,Zina Jeyapalan Rutnam,Burton B. Yang,Burton B. Yang +15 more
TL;DR: This study demonstrates that miR-378 is a regulator of stem cell marker Sox2 by targeting vimentin, which may serve as a new tool in studying the role of stem cells in tumorigenesis.