L
Lars T. Piehler
Researcher at University of Michigan
Publications - 25
Citations - 2081
Lars T. Piehler is an academic researcher from University of Michigan. The author has contributed to research in topics: Dendrimer & Internal medicine. The author has an hindex of 12, co-authored 22 publications receiving 2027 citations. Previous affiliations of Lars T. Piehler include Michigan Molecular Institute & United States Army Research Laboratory.
Papers
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Journal ArticleDOI
Design and Function of a Dendrimer-Based Therapeutic Nanodevice Targeted to Tumor Cells Through the Folate Receptor
Antonio Quintana,Ewa Raczka,Lars T. Piehler,Inhan Lee,Andrzej Myc,Istvan J. Majoros,Anil K. Patri,Thommey P. Thomas,James J. Mulé,James R. Baker +9 more
TL;DR: These results demonstrate the ability to design and produce polymer-based nanodevices for the intracellular targeting of drugs, imaging agents, and other materials.
Patent
Bioactive and/or targeted dendrimer conjugates
Donald A. Tomalia,James R. Baker,Anna U. Bielinska,Roberta C. Cheng,Fazio Michael J,David M. Hedstrand,Jennifer Johnson,Scott L. Klakamp,William J. Kruper,Jolanta F. Kukowska-Latallo,Bartley D. Maxon,Lars T. Piehler,Ian A. Tomlinson,Larry R. Wilson,Rui Yin,Donald A Kaplan +15 more
TL;DR: Dendritic polymer conjugates which are composed of at least one dendrimer in association with a carried material, where the carrier material can be a biological response modifier, have been prepared as mentioned in this paper.
Journal ArticleDOI
Inhibition of viral adhesion and infection by sialic-acid-conjugated dendritic polymers.
Jon D. Reuter,Andrzej Myc,Michael M. Hayes,Zhonghong Gan,René Roy,Dujie Qin,Rui Yin,Lars T. Piehler,Roseita Esfand,Donald A. Tomalia,James R. Baker +10 more
TL;DR: Significant (p < 0.001) dose-dependent reduction of influenza infection in mammalian cells by polymeric inhibitors is demonstrated, the first such demonstration for multivalent SA inhibitors.
Journal ArticleDOI
Visualization and Characterization of Poly(amidoamine) Dendrimers by Atomic Force Microscopy
TL;DR: In this paper, a tapping mode atomic force microscopy (AFM) image of poly(amidoamine), or PAMAM, dendrimers in the G5−G10 range was shown to be monodispersed, dome-shaped and randomly distributed on the mica surface.
Journal ArticleDOI
Prevention of Influenza Pneumonitis by Sialic Acid–Conjugated Dendritic Polymers
Jeffrey J. Landers,Zhengyi Cao,Inhan Lee,Lars T. Piehler,Piotr P. Myc,Andrzej Myc,Tarek Hamouda,Andrzej T. Galecki,James R. Baker +8 more
TL;DR: In vivo experiments showed that G4-SA completely prevented infection by a H3N2 subtype in a murine influenza pneum onitis model but was not effective in preventing pneumonitis caused by an H2N 2 subtype.