Lars W. Andersen

TL;DR: An overview of the pathogenesis of lactate level elevation is provided followed by an in-depth look at the varied etiologies, including medication-related causes, as well as some general recommendations on the management of patients with elevated lactate levels.

TL;DR: Although multiple individual factors are associated with outcomes, a multifaceted approach considering both potential for neurological recovery and ongoing multiorgan failure is warranted for prognostication and clinical decision-making in the post–cardiac arrest period.

TL;DR: The rate of adult cardiac arrests increased over time, while pediatric events remained more stable, while the number of in-hospital cardiac arrests among hospitalized patients remained the same.

TL;DR: Administration of thiamine did not improve lactate levels or other outcomes in the overall group of patients with septic shock and elevated lactate and a statistically significant decrease in mortality over time was not found.

TL;DR: The International Liaison Committee on Resuscitation Advanced Life Support Task Force performed a systematic review to evaluate three key questions: (1) Should mild induced hypothermia (or some form of targeted temperature management) be used in comatose post-cardiac arrest patients? (2) If used, what is the ideal timing of the intervention? (3) if used,What is the optimal duration of the treatment intervention? The task force used Grading of Recommendations Assessment, Development and Evaluation methodology to assess and summarize the evidence and to provide a consensus on science statement and