L
Laszlo Tora
Researcher at French Institute of Health and Medical Research
Publications - 207
Citations - 19760
Laszlo Tora is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Transcription factor II D & RNA polymerase II. The author has an hindex of 73, co-authored 204 publications receiving 18564 citations. Previous affiliations of Laszlo Tora include Centre national de la recherche scientifique & Tokyo University of Agriculture.
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Journal ArticleDOI
Two distinct estrogen‐regulated promoters generate transcripts encoding the two functionally different human progesterone receptor forms A and B.
Philippe Kastner,Andrée Krust,Bernard Turcotte,U. Stropp,Laszlo Tora,Hinrich Gronemeyer,Pierre Chambon +6 more
TL;DR: Using the hPR gene 5′‐flanking sequences as promoter region in chimeric genes, it is shown that a functional promoter directs initiation of hPR mRNAs from the authentic start sites located at +1 and +15.
Journal ArticleDOI
Polyglutamine expansion as a pathological epitope in Huntington's disease and four dominant cerebellar ataxias
Yvon Trottier,Yves Lutz,Giovanni Stevanin,Georges Imbert,Didier Devys,Géraldine Cancel,Frédéric Saudou,Chantal Weber,Gilles David,Laszlo Tora,Yves Agid,Alexis Brice,Jean-Louis Mandel +12 more
TL;DR: The characterization of a monoclonal antibody is reported that selectively recognizes polyglutamine expansion in the proteins implicated in HD and in spinocerebellar ataxia (SCA) 1 and 3 and detects specific pathological proteins expected to contain such expansion.
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The N-terminal part of TIF1, a putative mediator of the ligand-dependent activation function (AF-2) of nuclear receptors, is fused to B-raf in the oncogenic protein T18.
B Le Douarin,C. Zechel,Jean-Marie Garnier,Yves Lutz,Laszlo Tora,P. Pierrat,David M. Heery,Hinrich Gronemeyer,Pierre Chambon,Régine Losson +9 more
TL;DR: It is proposed that TIF1, which contains several conserved domains found in transcriptional regulatory proteins, is a mediator of ligand‐dependent AF‐2, and the N‐terminal moiety is fused to B‐raf in the mouse oncoprotein T18.
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Collisions between Replication and Transcription Complexes Cause Common Fragile Site Instability at the Longest Human Genes
TL;DR: The results show that, on the longest human genes, collisions of the transcription machinery with a replication fork are inevitable, creating R-loops and consequent CFS formation, and functional replication machinery needs to be involved in the resolution of conflicts between transcription and replication machineries to ensure genomic stability.
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Functional interference between hypoxia and dioxin signal transduction pathways: competition for recruitment of the Arnt transcription factor.
Katarina Gradin,Jacqueline McGuire,Roland H. Wenger,Ivica Kvietikova,M L fhitelaw,Rune Toftgård,Laszlo Tora,Max Gassmann,Lorenz Poellinger +8 more
TL;DR: It is demonstrated that HIF-1 alpha required Arnt for DNA binding in vitro and functional activity in vivo, and observed that Hif-1alpha was associated with the molecular chaperone hsp90, possibly by binding an as yet unknown class of ligands.