R
Roland H. Wenger
Researcher at Leipzig University
Publications - 44
Citations - 12086
Roland H. Wenger is an academic researcher from Leipzig University. The author has contributed to research in topics: Erythropoietin & Hypoxia-inducible factors. The author has an hindex of 31, co-authored 34 publications receiving 11465 citations. Previous affiliations of Roland H. Wenger include University of Zurich & University of Lübeck.
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Journal ArticleDOI
Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1α
Narayan V. Iyer,Lori E. Kotch,Faton Agani,Sandra W. Leung,Erik Laughner,Roland H. Wenger,Max Gassmann,John D. Gearhart,Ann M. Lawler,Aimee Y. Yu,Gregg L. Semenza +10 more
TL;DR: It is demonstrated that HIF-1alpha is a master regulator of cellular and developmental O2 homeostasis in Hif1a-/- embryos that manifested neural tube defects, cardiovascular malformations, and marked cell death within the cephalic mesenchyme.
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Cellular adaptation to hypoxia: O2-sensing protein hydroxylases, hypoxia-inducible transcription factors, and O2-regulated gene expression
TL;DR: This review aims to summarize the current knowledge of oxygen‐regulated gene expression, which includes the finding that HIF‐1 regulates the expression of many more genes apart from erythropoietin, and the elucidation of the oxygen‐dependent mechanisms degrading the HIF a subunits.
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Integration of Oxygen Signaling at the Consensus HRE
TL;DR: Compilations of theknown growth stimuli that promote increases in HIF abundance, of protein-protein interactions involving HIF, and of the known HIF effector genes are provided to aid in the identification of novel HIF target genes, design of oxygen-regulated gene therapy, and prediction of effects of future drugs targeting the HIF system.
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HIF-1 is expressed in normoxic tissue and displays an organ-specific regulation under systemic hypoxia
Deborah Stroka,Tobias Burkhardt,Isabelle Desbaillets,Roland H. Wenger,Desley Neil,Christian Bauer,Max Gassmann,Daniel Candinas +7 more
TL;DR: Immunohisto‐chemical examination of brain, kidney, liver, heart, and skeletal muscle revealed that HIF‐1α is present in mice kept under normoxic conditions and is further in‐creased in response to systemic hypoxia, suggesting that Hifer 1 has an important role in tissue homeostasis.
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Erythropoietin gene expression in human, monkey and murine brain.
Hugo H. Marti,Roland H. Wenger,L A Rivas,U. Straumann,Murat Digicaylioglu,V Henn,Yasuhiro Yonekawa,C. Bauer,Max Gassmann +8 more
TL;DR: It is shown that cerebral erythropoietin and its receptor are expressed in the brain of primates as they are in rodents, and that, at least in mice, primary astrocytes are a source of cerebral eriespheric expression which can be up‐regulated by reduced oxygenation.