Laura A. Lindsey-Boltz

TL;DR: The molecular mechanisms of DNA repair and the DNA damage checkpoints in mammalian cells are analyzed and apoptosis, which eliminates heavily damaged or seriously deregulated cells, is analyzed.

TL;DR: Functional similarities between the replication and checkpoint clamp loader/DNA clamp pairs are demonstrated and Electron microscopic analyses of the reaction products indicate that the 9-1-1 ring is clamped around the DNA.

TL;DR: The circadian clock plays an important role in determining the strengths of cellular responses to DNA damage including repair, checkpoints, and apoptosis, and new insights are expected to guide development of novel mechanism‐based chemotherapeutic regimens.

TL;DR: Findings constitute biochemical support for models regarding the roles of checkpoint Rads as damage sensors in the DNA damage checkpoint response of human cells.

TL;DR: It is found that the XPA protein, which plays an essential role in repair of cisplatin damage by nucleotide excision repair, exhibits circadian oscillation in the liver but not in testis, and the circadian oscillations of XPA is achieved both by regulation of transcription by the core circadian clock proteins including cryptochrome and by regulation at the posttranslational level by the HERC2 ubiquitin ligase.