J
Jerard Hurwitz
Researcher at Memorial Sloan Kettering Cancer Center
Publications - 349
Citations - 29350
Jerard Hurwitz is an academic researcher from Memorial Sloan Kettering Cancer Center. The author has contributed to research in topics: DNA replication & DNA polymerase. The author has an hindex of 94, co-authored 349 publications receiving 28675 citations. Previous affiliations of Jerard Hurwitz include United States Public Health Service & Washington University in St. Louis.
Papers
More filters
Journal ArticleDOI
Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex
Philip D. Jeffrey,Alicia A. Russo,Kornelia Polyak,Emma Gibbs,Jerard Hurwitz,Joan Massagué,Nikola P. Pavletich +6 more
TL;DR: The crystal structure of the human cyclinA-cyclin-dependent kinase2-ATP complex has been determined at 2.3 A resolution and activates the kinase by realigning active site residues and relieving the steric blockade at the entrance of the catalytic cleft.
Journal ArticleDOI
The formation of 2-keto-3-deoxyheptonic acid in extracts of Escherichia coli B. I. Identification.
Journal ArticleDOI
Structure of the C-Terminal Region of p21WAF1/CIP1 Complexed with Human PCNA
Jacqueline M Gulbis,Zvi Kelman,Jerard Hurwitz,Mike O'Donnell,Mike O'Donnell,John Kuriyan,John Kuriyan +6 more
TL;DR: The crystal structure of the human DNA polymerase delta processivity factor PCNA (proliferating cell nuclear antigen) complexed with a 22 residue peptide derived from the C-terminus of the cell-cycle checkpoint protein p21(WAF1/CIP1) has been determined at 2.6 angstrom resolution.
Journal ArticleDOI
Cell-cycle inhibition by independent CDK and PCNA binding domains in p21Cip1.
TL;DR: When separately overexpressed in mammalian cells, the CDK and PCNA inhibitory domains prevent DNA replication, demonstrating a dual function of p21 as a cell-cycle inhibitor in vivo.
Journal ArticleDOI
RNA Helicase A Mediates Association of CBP with RNA Polymerase II
Toshihiro Nakajima,Chiharu Uchida,Stephen Anderson,Chee-Gun Lee,Jerard Hurwitz,Jeffrey D. Parvin,Marc Montminy +6 more
TL;DR: It is shown that complex formation between CBP and RNA polymerase II requires RNA helicase A (RHA), a nuclear DNA/RNA helicase that is related to the Drosophila male dosage compensation factor mle.