L
Laura A. St Clair
Researcher at Colorado State University
Publications - 9
Citations - 70
Laura A. St Clair is an academic researcher from Colorado State University. The author has contributed to research in topics: Biology & Viral replication. The author has an hindex of 2, co-authored 3 publications receiving 12 citations.
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SARS-CoV-2 infection triggers widespread host mRNA decay leading to an mRNA export block.
TL;DR: In this paper, the expression and localization of host mRNAs during SARS-CoV-2 infection were examined using single-molecule RNA visualization, and it was shown that the biogenesis of type I and type III IFN genes is inhibited at multiple steps during infection.
Journal ArticleDOI
RNase L activation in the cytoplasm induces aberrant processing of mRNAs in the nucleus
James M. Burke,Nina Ripin,Max Ferretti,Laura A. St Clair,Emma R Worden-Sapper,Fernando Salgado,Sara L. Sawyer,Rushika M. Perera,Kristen W. Lynch,Roy Parker +9 more
TL;DR: In this paper , it was shown that RNA-binding proteins (RBPs) translocate from the cytoplasm to the nucleus upon RNase L activation due to the presence of intact nuclear RNA.
Journal ArticleDOI
The 18th Rocky Mountain Virology Association Meeting.
TL;DR: The main area of focus was on host–virus interactions, however other areas of interest included virus vectors, current models of virus infections, prevention and treatment of viruses infections, separate sessions on RNA viruses and prion proteins, and a special talk highlighting various attributes of targeted next-generation sequencing.
Journal ArticleDOI
Rapid Decay of Host Basal mRNAs During SARS-CoV-2 Infection Perturbs Host Antiviral mRNA Biogenesis and Export
TL;DR: This work shows SARS-CoV-2 infection limits type I and type III IFN biogenesis by preventing the release of mRNA from their sites of transcription and/or triggering their nuclear degradation, which may reduce viral-associated pathogenesis by promoting the innate immune response.
Posted ContentDOI
RNase L-mediated RNA decay alters 3’ end formation and splicing of host mRNAs
James M. Burke,Nina Ripin,Max Ferretti,Laura A. St Clair,Emma R Worden-Sapper,Sara L. Sawyer,Rushika M. Perera,Kristen W. Lynch,Roy Parker +8 more
TL;DR: It is revealed that the distribution of RBPs between the nucleus and cytosol is fundamentally dictated by the availability of RNA in each compartment and thus viral infections that trigger cytoplasmic RNA degradation alter RNA processing due to the nuclear influx of RNA binding proteins.