Laura F. Steel

TL;DR: It is shown that woodchuck diagnosed with HCC have dramatically higher levels of serum-associated core alpha-1,6-linked fucose, as compared with woodchucks without a diagnosis of HCC, providing a validation of the approach.

TL;DR: Higher levels of GP73 can be found in the serum of patients with HCC than of those without, and GP73 was better than AFP for the diagnosis of early HCC.

TL;DR: Using monoclonal antibodies against human serum albumin (HSA) to develop an immunoaffinity resin that is effective in the removal of both full-length HSA and many of the HSA fragments present in serum shows markedly better performance than dye-based resins in terms of both the efficiency and specificity of albumin removal.

TL;DR: Preliminary studies suggest that a proteomic methodology can be used for the identification of serum biomarkers for HCC and other liver disease.

TL;DR: SELDI‐TOF MS serum profiling is able to distinguish HCC from liver disease before cirrhosis as well as Cirrhosis, especially in patients with HCV infection compared with other etiologies.