Laura Nicolaou

TL;DR: In vitro deposition measurements have been conducted in a human‐based model of the upper airways, and several groups within MP1404 SimInhale have computed the same case using a variety of simulation and discretization approaches, and a critical discussion of the performance of the various simulation methods is provided.

TL;DR: In this paper, the role of the extrathoracic airway in determining regional deposition in the upper bronchial airway was assessed. And the results suggest that accurate predictions of regional deposition of inhaled medicines can therefore be obtained if the particle size distribution that escapes filtering in the mouth-throat (excast dose) of a particular patient is known or can be estimated.

TL;DR: In this paper, a set of realistic mouth-throat geometries at a flow rate of 30 L/min is studied in order to determine the effect of intrasubject and intersubject variations on the mean flow patterns and the turbulence fluctuations.

TL;DR: An iterative approach to compute the forcing term implicitly is proposed, which reduces the errors at the boundary and retains the stability guarantees of the original semi-implicit discretization of the Navier–Stokes equations.

TL;DR: In this article, Laminar and turbulent flows in a curved pipe are examined first and provide a simplified, or canonical, configuration of the flow in the upper airways, followed by a study of turbulent flow in an idealized mouth-throat geometry.