L
Laura Pintado-Berninches
Researcher at Spanish National Research Council
Publications - 19
Citations - 246
Laura Pintado-Berninches is an academic researcher from Spanish National Research Council. The author has contributed to research in topics: Telomerase & Telomere. The author has an hindex of 10, co-authored 18 publications receiving 170 citations. Previous affiliations of Laura Pintado-Berninches include Autonomous University of Madrid & Hospital Universitario La Paz.
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Journal ArticleDOI
Development of surface modified biodegradable polymeric nanoparticles to deliver GSE24.2 peptide to cells: a promising approach for the treatment of defective telomerase disorders.
Susana P. Egusquiaguirre,Cristina Manguan-García,Laura Pintado-Berninches,Laura Iarriccio,Daniel Carbajo,Fernando Albericio,Miriam Royo,José Luis Pedraz,Rosa Maria Hernandez,Rosario Perona,Manuela Igartua +10 more
TL;DR: Results proved that GSE24.2-loaded NPs could be delivered to cells, and therefore, become an effective approach for the treatment of DC and other defective telomerase syndromes.
Journal ArticleDOI
Expression of the genetic suppressor element 24.2 (GSE24.2) decreases DNA damage and oxidative stress in X-linked dyskeratosis congenita cells.
Cristina Manguan-García,Laura Pintado-Berninches,Jaime Carrillo,Rosario Machado-Pinilla,Leandro Sastre,Carme Perez-Quilis,Isabel Esmoris,Amparo Gimeno,José Luis García-Giménez,Federico V. Pallardó,Rosario Perona +10 more
TL;DR: Data indicated that supplying GSE24.2, either from a cDNA vector or as a peptide reduces the pathogenic effects of Dkc1 mutations and suggests a novel therapeutic approach.
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High expression of MKP1/DUSP1 counteracts glioma stem cell activity and mediates HDAC inhibitor response
Olatz Arrizabalaga,Leire Moreno-Cugnon,Jaione Auzmendi-Iriarte,Paula Aldaz,Inmaculada Ibáñez de Cáceres,Laura Garros-Regulez,Veronica Moncho-Amor,Sergio Torres-Bayona,Olga Pernía,Laura Pintado-Berninches,Patricia Carrasco-Ramírez,María Cortes-Sempere,Rocío Rosas,Pilar Sánchez-Gómez,Irune Ruiz,Helena Carén,Steven M. Pollard,Idoia Garcia,Angel-Ayuso Sacido,Robin Lovell-Badge,Cristobal Belda-Iniesta,Nicolás Samprón,Rosario Perona,Ander Matheu +23 more
TL;DR: MKP1 is identified as a key modulator of the interplay between GSC self-renewal and differentiation and evidence that the activation of MKP1, through epigenetic regulation, might be a novel therapeutic strategy to overcome therapy resistance in glioblastoma is provided.
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SOSTDC1 promotes invasion and liver metastasis in colorectal cancer via interaction with ALCAM/CD166
Rubén Álvaro Bartolomé,Laura Pintado-Berninches,Marta Jaén,Vivian de los Ríos,Juan I. Imbaud,J. Ignacio Casal +5 more
TL;DR: SOSTDC1 promotes invasion and liver metastasis in colorectal cancer, by overcoming BMP4-specific antimetastatic signals and inducing ALCAM-mediated Src and PI3K/AKT activation.
Journal ArticleDOI
Genetic analyses of aplastic anemia and idiopathic pulmonary fibrosis patients with short telomeres, possible implication of DNA-repair genes
Elena G Arias-Salgado,Eva M. Galvez,Lurdes Planas-Cerezales,Laura Pintado-Berninches,Elena Vallespín,P. Martínez,Jaime Carrillo,Laura Iarriccio,Anna Ruiz-Llobet,Albert Català,Isabel Badell-Serra,Luis Ignacio Gonzalez-Granado,Andrea Martín-Nalda,Mónica Martínez-Gallo,Ana Maria Galera-Miñarro,Carmen Rodríguez-Vigil,Mariana Bastos-Oreiro,Guiomar Perez de Nanclares,Virginia Leiro-Fernandez,Maria-Luz Uria,Cristina Diaz-Heredia,Claudia Valenzuela,Sara Martín,Belén López-Muñiz,Pablo Lapunzina,Julián Sevilla,Maria Molina-Molina,Rosario Perona,Leandro Sastre +28 more
TL;DR: Novel variants in telomere, DNA repair and replication genes are described that might indicate the contribution of variants in these genes to the development of telomeropathies.