Laura Reiche

TL;DR: Findings indicate a critical window of opportunity during which regenerative oligodendroglial activities including myelination of CNS axons can be stimulated by teriflunomide, and suggest that young, immature cells could benefit from such stimulation.

TL;DR: To what degree DS-related effects on oligodendroglial cells have been described and to what degree induced cell-fate switches are presented, thereby resulting in an enhanced generation of astrocytes are discussed.

TL;DR: In this paper, a phenotypic compound screening using the subcellular distribution of a potent inhibitor of oligodendroglial cell differentiation, namely p57kip2, was conducted.

TL;DR: In this paper, the role of C21orf91 ortholog in terms of oligodendrogenesis and myelination using database information as well as through cultured primary OCL precursor cells was investigated.

TL;DR: Under healthy conditions intrinsic suppression of p57kip2 as well as WM localization promote differentiation toward myelinating oligodendrocytes at the expense of astrocyte generation, which further reveals critical factors when considering aNSC mediated cell replacement in injury and disease.