P
Peter Göttle
Researcher at University of Düsseldorf
Publications - 33
Citations - 871
Peter Göttle is an academic researcher from University of Düsseldorf. The author has contributed to research in topics: Remyelination & Myelin. The author has an hindex of 15, co-authored 28 publications receiving 634 citations.
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Journal ArticleDOI
Activation of CXCR7 receptor promotes oligodendroglial cell maturation.
Peter Göttle,David Kremer,Sebastian Jander,Veysel Ödemis,Jürgen Engele,Hans-Peter Hartung,Patrick Küry +6 more
TL;DR: This work investigated whether the chemokine CXCL12 influences oligodendrocytes and what cellular differentiation/maturation processes are controlled by this molecule.
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Pushing Forward: Remyelination as the New Frontier in CNS Diseases
TL;DR: CNS pathologies characterized by white matter degeneration and regeneration are discussed and drugs that could potentially serve as remyelination therapies are highlighted.
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pHERV-W envelope protein fuels microglial cell-dependent damage of myelinated axons in multiple sclerosis.
David Kremer,Joel Gruchot,Vivien Weyers,Lisa Oldemeier,Peter Göttle,Luke M. Healy,Jeong Ho Jang,Yu Kang T. Xu,Christina Volsko,Ranjan Dutta,Bruce D. Trapp,Hervé Perron,Hans-Peter Hartung,Patrick Küry +13 more
TL;DR: The data suggest that pHERV-W ENV-mediated microglial polarization contributes to neurodegeneration in MS, and provides a neurobiological rationale for a recently completed clinical study in MS patients showing that antibody-mediated neutralization of pHERVs exerts neuroprotective effects.
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The Molecular Basis for Remyelination Failure in Multiple Sclerosis
Joel Gruchot,Vivien Weyers,Peter Göttle,Moritz Förster,Hans-Peter Hartung,Patrick Küry,David Kremer +6 more
TL;DR: The molecular factors contributing to remyelination failure in MS are reviewed by inhibiting OPC and NSC differentiation or modulating microglial behavior.
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The cyclin-dependent kinase inhibitor p57kip2 is a negative regulator of Schwann cell differentiation and in vitro myelination
André Heinen,David Kremer,Peter Göttle,Fabian Kruse,Birgit Hasse,Helmar C. Lehmann,Hans-Peter Hartung,Patrick Küry +7 more
TL;DR: It is found that gene knockdown by means of vector-based RNA interference in cultured primary Schwann cells found that reduced levels of p57kip2 lead to cell cycle exit, actin filament stabilization, altered cell morphology and growth, and down-regulation of promyelinating markers as as induction of myelin genes and proteins.