Lauren K. Wood

TL;DR: It is reported here that many forms of age‐dependent change, including alterations in heart, liver, adrenal glands, endometrium, and tendon, as well as age-dependent decline in spontaneous activity, occur more slowly in rapamycin‐treated mice, suggesting strongly thatRapamycin retards multiple aspects of aging in mice, in addition to any beneficial effects it may have on neoplastic disease.

TL;DR: Findings indicate that theECM of tibialis anterior muscles from old mice has a higher modulus than the ECM of adult muscles, likely driven by an accumulation of densely packed extensively crosslinked collagen.

TL;DR: It is concluded that TA tendons stiffen in a region-dependent manner throughout the life span, but the changes in mechanical properties are not accompanied by corresponding changes in collagen fibril morphology or force-generating capacity of the TA muscle.

TL;DR: It is demonstrated that tendons from old animals are capable of replacing damaged and dysfunctional components of extracellular matrix with tissue that is mechanically and structurally comparable to adult tissue in response to exercise.

TL;DR: Eight whole fresh-frozen cadavers that were elderly and/or female were laterally impacted using UMTRI's dual-sled side-impact test facility using a thinly padded, multi-segment impactor that independently measured force histories applied to the shoulder, thorax, abdomen, greater trochanter, iliac wing, and femur of each PMHS.