L
Laurence D. Hurst
Researcher at University of Bath
Publications - 310
Citations - 24738
Laurence D. Hurst is an academic researcher from University of Bath. The author has contributed to research in topics: Gene & Genome. The author has an hindex of 76, co-authored 296 publications receiving 22836 citations. Previous affiliations of Laurence D. Hurst include University of Chicago & University of Oxford.
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Late-Replicating Domains Have Higher Divergence and Diversity in Drosophila melanogaster
TL;DR: There is indeed a relationship between rates of nucleotide divergence and diversity and replication timing that is consistent with an increase in the mutation rate during late S-phase in D. melanogaster, and it is therefore plausible that such an effect might be common among eukaryotes.
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Co-expressed Yeast Genes Cluster Over a Long Range but are not Regularly Spaced
TL;DR: Analysis in yeast of the relationship between a gene's genomic position and its expression profile, derived from chip array data, suggests that both closely linked genes and genes spaced at regular intervals show correlated expression profiles, but there is no evidence for periodicity of co-expression in yeast.
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A comparative test of a theory for the evolution of anisogamy
TL;DR: This model predicts disruptive selection on gamete size if increases in zygote size confer disproportional increases in fitness (at least over part of its size range), and predicts that increases in adult size should be accompanied by stronger selection for anisogamy.
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Atypical at skew in Firmicute genomes results from selection and not from mutation.
Catherine A. Charneski,Frank Honti,Frank Honti,Josephine M. Bryant,Josephine M. Bryant,Laurence D. Hurst,Edward J. Feil +6 more
TL;DR: The atypical AT skew is shown to be a consequence of the strong bias for genes to be co-oriented with the replicating fork, coupled with the selective avoidance of both stop codons and costly amino acids, which tend to have T-rich codons.
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The evolution of concerted evolution
TL;DR: It is predicted that genes for which mutations may often be dominant or semi–dominant should undergo concerted evolution more commonly than others, and that selection will favour homogenization of such genes, and possibly others that are significantly dosage dependent, more often than it favours homogenized in other genes.