L
Laurence D. Hurst
Researcher at University of Bath
Publications - 310
Citations - 24738
Laurence D. Hurst is an academic researcher from University of Bath. The author has contributed to research in topics: Gene & Genome. The author has an hindex of 76, co-authored 296 publications receiving 22836 citations. Previous affiliations of Laurence D. Hurst include University of Chicago & University of Oxford.
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Selfish Genetic Elements and their Role in Evolution: The Evolution of Sex and Some of What that Entails
TL;DR: This work has shown that sexes are the result of selection on nuclear genes to coordinate the inheritance of cytoplasmic genomes so as to prevent competition between unrelated cy toplasmics genomes and this hypothesis is tested against five comparative predictions and shown to receive considerable empirical support.
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Male killing can select for male mate choice: a novel solution to the paradox of the lek.
TL;DR: This work model the evolution of a male choice gene that allows discrimination between infected and uninfected females, and shows that the stable maintenance of both female variation and male choice is likely, so long as males make mistakes when discriminating between females.
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Active and repressed biosynthetic gene clusters have spatially distinct chromosome states
Hans Wilhelm Nützmann,Daniel Doerr,América Ramírez-Colmenero,Jesús Emiliano Sotelo-Fonseca,Eva Wegel,Marco Di Stefano,Steven W. Wingett,Peter Fraser,Laurence D. Hurst,Selene L. Fernandez-Valverde,Anne Osbourn +10 more
TL;DR: It is demonstrated that plant biosynthetic gene clusters reside in highly interactive domains that undergo marked changes in local conformation and nuclear positioning in cluster expressing and nonexpressing organs and suggested that gene clustering in the one-dimensional chromosome is accompanied by compartmentalization of the 3D chromosome.
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The effect of tandem substitutions on the correlation between synonymous and nonsynonymous rates in rodents
TL;DR: The cause of the correlation between the substitution rates at nonsynonymous and synonymous sites in mammals is investigated, and selection for RNA structure may affect silent sites in mammalian protein-coding genes.
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Vertebrate genome evolution: a slow shuffle or a big bang?
TL;DR: With more extensive sequencing and mapping of vertebrate genomes, especially those of the early diverging chordates, it should soon become possible to resolve the origins of homologous clusters.