L
Laurence J. Marton
Researcher at University of California, San Francisco
Publications - 235
Citations - 10205
Laurence J. Marton is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Polyamine & Spermine. The author has an hindex of 49, co-authored 235 publications receiving 9878 citations. Previous affiliations of Laurence J. Marton include Penn State Milton S. Hershey Medical Center & Wisconsin Alumni Research Foundation.
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Journal ArticleDOI
Polyamines as Targets for Therapeutic Intervention
TL;DR: Protocols minimizing uptake of exogenous polyamines via the polyamine-transport system will probably be needed for the full potential of inhibitors of ornithine decarboxylase to be realized.
Journal ArticleDOI
Targeting polyamine metabolism and function in cancer and other hyperproliferative diseases
TL;DR: The polyamines spermidine and spermine and their diamine precursor putrescine are naturally occurring, polycationic alkylamines that are essential for eukaryotic cell growth and are frequently dysregulated in cancer and other hyperproliferative diseases.
Journal ArticleDOI
Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia
Tino Schenk,Weihsu Claire Chen,Stefanie Göllner,Louise Howell,Liqing Jin,Katja Hebestreit,Hans-Ulrich Klein,Andreea C. Popescu,Alan Kenneth Burnett,Ken I. Mills,Robert A. Casero,Laurence J. Marton,Patrick M. Woster,Mark D. Minden,Martin Dugas,Jean C.Y. Wang,Jean C.Y. Wang,John E. Dick,John E. Dick,Carsten Müller-Tidow,Kevin Petrie,Arthur Zelent +21 more
TL;DR: Data identify LSD1 as a therapeutic target and strongly suggest that it may contribute to AML pathogenesis by inhibiting the normal pro-differentiative function of ATRA, paving the way for new combinatorial therapies for AML.
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Subtype and pathway specific responses to anticancer compounds in breast cancer.
Laura M. Heiser,Anguraj Sadanandam,Wen-Lin Kuo,Stephen C. Benz,Theodore C. Goldstein,Sam Ng,William J. Gibb,Nicholas J. Wang,Safiyyah Ziyad,Frances Tong,Nora Bayani,Zhi Hu,Jessica Billig,Andrea Dueregger,Sophia Lewis,Lakshmi Jakkula,James E. Korkola,Steffen Durinck,François Pepin,Yinghui Guan,Elizabeth Purdom,Pierre Neuvial,Henrik Bengtsson,Kenneth Wood,Pete Smith,Lyubomir T. Vassilev,Bryan T. Hennessy,Joel Greshock,Kurtis E. Bachman,Mary Ann Hardwicke,John W. Park,Laurence J. Marton,Denise M. Wolf,Eric A. Collisson,Richard M. Neve,Gordon B. Mills,Terence P. Speed,Heidi S. Feiler,Richard Wooster,David Haussler,Joshua M. Stuart,Joe W. Gray,Paul T. Spellman +42 more
TL;DR: In this paper, a test of 77 therapeutic compounds, nearly all drugs showed differential responses across these cell lines, and approximately one third showed subtype-, pathway-, and/or genomic aberration-specific responses.
Journal ArticleDOI
Ornithine decarboxylase is important in intestinal mucosal maturation and recovery from injury in rats.
TL;DR: Increased ornithine decarboxylase activity, with the resultant increase in polyamine content, may play an essential role in intestinal mucosal maturation and regeneration in the rat.