L
Laurence Lins
Researcher at Gembloux Agro-Bio Tech
Publications - 165
Citations - 6199
Laurence Lins is an academic researcher from Gembloux Agro-Bio Tech. The author has contributed to research in topics: Peptide & Lipid bilayer. The author has an hindex of 40, co-authored 164 publications receiving 5457 citations. Previous affiliations of Laurence Lins include University of Liège & Ghent University.
Papers
More filters
Journal ArticleDOI
Apolipoprotein L-I is the trypanosome lytic factor of human serum
Luc Vanhamme,Françoise Paturiaux-Hanocq,Philippe Poelvoorde,Derek P. Nolan,Derek P. Nolan,Laurence Lins,Jan Van Den Abbeele,Annette Pays,Patricia Tebabi,Huang Van Xong,Alain Jacquet,Nicole Moguilevsky,Marc Dieu,John P. Kane,Patrick De Baetselier,Robert Brasseur,Etienne Pays +16 more
TL;DR: In this paper, the amino-terminal alpha-helix of SRA was found to interact strongly with a carboxy terminal alpha helix of the human-specific serum protein apolipoprotein L-I (apoL-I).
Journal ArticleDOI
Apolipoprotein L-I Promotes Trypanosome Lysis by Forming Pores in Lysosomal Membranes
David Perez-Morga,Benoit Vanhollebeke,Françoise Paturiaux-Hanocq,Derek P. Nolan,Laurence Lins,Fabrice Homblé,Luc Vanhamme,Patricia Tebabi,Annette Pays,Philippe Poelvoorde,Alain Jacquet,Robert Brasseur,Etienne Pays +12 more
TL;DR: It is shown that this protein contains a membrane pore-forming domain functionally similar to that of bacterial colicins, flanked by a membrane-addressing domain that triggered depolarization of this membrane, continuous influx of chloride, and subsequent osmotic swelling of the lysosome until the trypanosome lysed.
Journal ArticleDOI
Analysis of accessible surface of residues in proteins.
TL;DR: This analysis points out a clear difference between the mean and median ASA values of hydrophobic residues, which should be taken into consideration for future investigations on a protein‐accessible surface, in order to improve predictions requiring ASA values.
Journal ArticleDOI
The hydrophobic effect in protein folding.
Laurence Lins,Robert Brasseur +1 more
TL;DR: In this review of protein folding, the electrostatic, Van dcr Waals, hydrogen bonding, and hydrophobic interactions are described and their contribution to protein conformation is discussed.
Journal ArticleDOI
Identification of key residues for interaction of vasoactive intestinal peptide with human VPAC1 and VPAC2 receptors and development of a highly selective VPAC1 receptor agonist. Alanine scanning and molecular modeling of the peptide.
Pascal Nicole,Laurence Lins,Christiane Rouyer-Fessard,Cyrille Drouot,Pierre Fulcrand,Annick Thomas,Alain Couvineau,Jean Martinez,Robert Brasseur,Marc Laburthe +9 more
TL;DR: The [Ala11,22,28]VIP analog is developed, which constitutes the first highly selective (>1,000-fold) human VPAC1 receptor agonist derived from VIP ever described.