L
Lawrence D. Wise
Researcher at Parke-Davis
Publications - 127
Citations - 2313
Lawrence D. Wise is an academic researcher from Parke-Davis. The author has contributed to research in topics: Dopamine & Dopamine receptor. The author has an hindex of 26, co-authored 127 publications receiving 2242 citations.
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Journal ArticleDOI
4-(1,2,5,6-Tetrahydro-1-alkyl-3-pyridinyl)-2-thiazolamines: a novel class of compounds with central dopamine agonist properties.
Juan C. Jaen,Lawrence D. Wise,Bradley William Caprathe,Haile Tecle,Stephen C. Bergmeier,Christine Humblet,Thomas G. Heffner,Leonard T. Meltzer,Thomas A. Pugsley +8 more
TL;DR: In this series, DA agonist activity was found to be highly dependent on the size of the N-alkyl substituent, the saturation level of the six-membered ring, and the mode of attachment of the 2-aminothiazole ring.
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Isoindolinone enantiomers having affinity for the dopamine D4 receptor
Thomas R. Belliotti,Wouter A. Brink,Suzanne R. Kesten,J. R. Rubin,David Juergen Wustrow,Kim T. Zoski,Steven Z. Whetzel,A E Corbin,Thomas A. Pugsley,Thomas G. Heffner,Lawrence D. Wise +10 more
TL;DR: Investigations led to the discovery of a series of isoindolinones having D4 affinity that were identified as a potent dopamine D4 ligand and replaced the benzylic alcohol with a metabolically more stable moiety.
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Autoradiographic localisation of D3-dopamine receptors in the human brain using the selective D3-dopamine receptor agonist (+)-[3H]PD 128907
Håkan Hall,Christer Halldin,Durk Dijkstra,Håkan Wikström,Lawrence D. Wise,Thomas A. Pugsley,Pierre Sokoloff,Stefan Pauli,Lars Farde,Göran Sedvall +9 more
TL;DR: The new compound [3H]PD 128907 appears to be a suitable radioligand for autoradiographic examination of the D3-dopamine receptor localisation in the human brain, and should also be useful for pharmacological studies of this receptor subtype.
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Substituted [(4-phenylpiperazinyl)- methyl]benzamides : Selective dopamine D4 agonists
Shelly A. Glase,Hyacinth C. Akunne,Lynn M. Georgic,Thomas G. Heffner,Robert G. MacKenzie,Peter J. Manley,Thomas A. Pugsley,Lawrence D. Wise +7 more
Journal ArticleDOI
Subtype-selective N-methyl-D-aspartate receptor antagonists: synthesis and biological evaluation of 1-(arylalkynyl)-4-benzylpiperidines.
Jon L. Wright,Tracy Fay Gregory,Suzanne Ross Kesten,Peter A. Boxer,Kevin A. Serpa,Leonard T. Meltzer,Lawrence D. Wise,Stephen A. Espitia,Christopher S. Konkoy,Edward R. Whittemore,Richard M. Woodward +10 more
TL;DR: The hydroxyl propyne and butyne were among the most potent NR1A/2B antagonists from this study and potentiated the effects of L-DOPA in the 6-hydroxydopamine-lesioned rat, a model of Parkinson's disease, but 48 was not active at 30 mg/kg po.