Laxman Ghimire

TL;DR: Ethanolic extracts of 16 different traditionally used medicinal plants of Nepal against 13 clinical and 2 reference bacterial species using microbroth dilution method were found to exert a range of in vitro growth inhibitory action against the tested bacterial species.

TL;DR: Findings identify CXCL1 as a central player in host defense, granulopoiesis, and mobilization of neutrophils during Gram-positive bacterial pneumonia-induced sepsis.

TL;DR: In this review, the recent advancements in knowledge of the signaling mechanisms and structure of the Nlrp6 inflammasome are summarized and the relevance of NLRP6 to human disease is discussed.

TL;DR: Novel findings show that NLRP6 serves as a negative regulator of neutrophil-mediated host defense during Gram-positive bacterial infection in the lungs through regulating both neutrophic influx and function, and suggest that blocking NLRP 6 to augment neutrophIL-associated bacterial clearance should be considered as a potential therapeutic intervention strategy for treatment of S. aureus pneumonia.

TL;DR: Emerging Roles of Inflammasomes in Acute Pneumonia and their Applications in Pulmonary and Critical Care Medicine is presented.