Laxman Nayak

TL;DR: Data implicate CMV as a major factor in driving oligoclonal expansions in old age and a dramatic accumulation of virus-specific effector CTL might impair the ability to respond to heterologous infection and may underlie the negative influence of CMV seropositivity on survival in the very elderly.

TL;DR: Examination of CD8 T cell responses to two persistent herpesvirus infections, CMV and EBV, and to a recurrent virus infection, influenza, in different age cohorts of healthy donors using HLA-peptide tetramers and intracellular cytokine detection suggests that carriage of CMV may be detrimental to the immunocompetent host by suppressing heterologous virus-specific immunity during aging.

TL;DR: It is demonstrated that the number of CD4+ CD25+’s T cells in healthy volunteers increases with age, and the relevance of these expanded cells in relation to the immune senescence seen in the elderly as yet remains unclear.

TL;DR: The influence of CMV‐seropositivity on the size of lymphoid subsets in healthy donors is studied and it is demonstrated that the virus substantially modulates the peripheral lymphoid pool.

TL;DR: The recording of the CD4+ T-cell immune response to CMV in healthy donors of different ages contributes to evidence that CMV infection may be damaging to immune function in elderly individuals.