R
Rajiv Khanna
Researcher at QIMR Berghofer Medical Research Institute
Publications - 265
Citations - 13642
Rajiv Khanna is an academic researcher from QIMR Berghofer Medical Research Institute. The author has contributed to research in topics: Antigen & Cytotoxic T cell. The author has an hindex of 61, co-authored 250 publications receiving 12422 citations. Previous affiliations of Rajiv Khanna include Commonwealth Scientific and Industrial Research Organisation & Post Graduate Institute of Medical Education and Research.
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Journal ArticleDOI
Immunobiology of Human Cytomegalovirus: from Bench to Bedside
Tania Crough,Rajiv Khanna +1 more
TL;DR: Over the last decade, knowledge of the immune response to HCMV infection in healthy virus carriers and diseased individuals has allowed us to translate these findings to develop better diagnostic tools and therapeutic strategies, and the application of these emerging technologies in the clinical setting is likely to provide opportunities for better management of patients with H CMV-associated diseases.
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Human cytomegalovirus: clinical aspects, immune regulation, and emerging treatments
Maher K. Gandhi,Rajiv Khanna +1 more
TL;DR: Immune-based therapies to complement pharmacological strategies for the successful treatment of virus-associated complications should be prospectively investigated.
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Localization of Epstein-Barr virus cytotoxic T cell epitopes using recombinant vaccinia: implications for vaccine development.
Rajiv Khanna,Scott R. Burrows,Michael G. Kurilla,C. A. Jacob,I. S. Misko,T. B. Sculley,Elliott Kieff,Denis J. Moss +7 more
TL;DR: The results suggest that any EBV vaccine based on CTL epitopes designed to provide widespread protection will need to include not only latent antigen sequences but also other regions of the genome.
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Herpesvirus-Specific CD8 T Cell Immunity in Old Age: Cytomegalovirus Impairs the Response to a Coresident EBV Infection
Naeem Khan,Andrew D. Hislop,Nancy H. Gudgeon,Mark Cobbold,Rajiv Khanna,Laxman Nayak,Alan B. Rickinson,Paul Moss +7 more
TL;DR: Examination of CD8 T cell responses to two persistent herpesvirus infections, CMV and EBV, and to a recurrent virus infection, influenza, in different age cohorts of healthy donors using HLA-peptide tetramers and intracellular cytokine detection suggests that carriage of CMV may be detrimental to the immunocompetent host by suppressing heterologous virus-specific immunity during aging.
Journal ArticleDOI
Ex Vivo Profiling of CD8+-T-Cell Responses to Human Cytomegalovirus Reveals Broad and Multispecific Reactivities in Healthy Virus Carriers
Rebecca Elkington,Susan Walker,Tania Crough,Moira L. Menzies,Judy Tellam,Mandvi Bharadwaj,Rajiv Khanna +6 more
TL;DR: It is found that successful HCMV-specific immune control in healthy virus carriers is dependent on a strong T-cell response towards a broad repertoire of antigens, which contrasts with previous findings that viral interference with the antigen-processing pathway during lytic infection would render immediate-early and early/late proteins less immunogenic.