L
Lea Baecker
Researcher at King's College London
Publications - 7
Citations - 189
Lea Baecker is an academic researcher from King's College London. The author has contributed to research in topics: Normative & Autoencoder. The author has an hindex of 5, co-authored 7 publications receiving 46 citations.
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Journal ArticleDOI
Neuroharmony: A new tool for harmonizing volumetric MRI data from unseen scanners
Rafael Garcia-Dias,Cristina Scarpazza,Lea Baecker,Sandra Vieira,Walter H. L. Pinaya,Aiden Corvin,Alberto Redolfi,Barnaby Nelson,Benedicto Crespo-Facorro,Colm McDonald,Diana Tordesillas-Gutiérrez,Dara M. Cannon,David Mothersill,Dennis Hernaus,Derek W. Morris,Esther Setién-Suero,Gary Donohoe,Giovanni B. Frisoni,Giulia Tronchin,João Sato,Machteld Marcelis,Matthew J. Kempton,Neeltje E.M. van Haren,Oliver Gruber,Patrick D. McGorry,Paul Amminger,Philip McGuire,Qiyong Gong,René S. Kahn,Rosa Ayesa-Arriola,Therese van Amelsvoort,Victor Ortiz-García de la Foz,Vince D. Calhoun,Wiepke Cahn,Andrea Mechelli +34 more
TL;DR: Neuroharmony, a harmonization tool for images from unseen scanners, was able to reduce scanner-related bias from unseen scans and represents a significant step towards imaging-based clinical tools.
Journal ArticleDOI
Machine learning for brain age prediction: Introduction to methods and clinical applications
Lea Baecker,Rafael Garcia-Dias,Sandra Vieira,Cristina Scarpazza,Cristina Scarpazza,Andrea Mechelli +5 more
TL;DR: A review of the state-of-the-art methods and potential clinical applications of brain age prediction can be found in this paper, where a regression machine learning model of age-related neuroanatomical changes in healthy people is used to predict brain age.
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Brain age prediction: A comparison between machine learning models using region- and voxel-based morphometric data.
Lea Baecker,Jessica Dafflon,Pedro F. da Costa,Rafael Garcia-Dias,Sandra Vieira,Cristina Scarpazza,Cristina Scarpazza,Vince D. Calhoun,Vince D. Calhoun,João Ricardo Sato,Andrea Mechelli,Walter H. L. Pinaya,Walter H. L. Pinaya +12 more
TL;DR: In this paper, the authors compared the performance of support vector regression, relevance vector regression and Gaussian process regression on whole-brain region-based or voxel-based structural magnetic resonance imaging data with or without dimensionality reduction through principal component analysis.
Journal ArticleDOI
Translating research findings into clinical practice: a systematic and critical review of neuroimaging-based clinical tools for brain disorders.
Cristina Scarpazza,Cristina Scarpazza,M. Ha,Lea Baecker,Rafael Garcia-Dias,Walter H. L. Pinaya,Walter H. L. Pinaya,Sandra Vieira,Andrea Mechelli +8 more
TL;DR: This systematic review describes and compares the technical characteristics of the available tools, and proposes a checklist of pivotal characteristics that should be included in an “ideal” neuroimaging-based clinical tool for brain disorders.
Journal ArticleDOI
Using normative modelling to detect disease progression in mild cognitive impairment and Alzheimer's disease in a cross-sectional multi-cohort study.
Walter H. L. Pinaya,Walter H. L. Pinaya,Cristina Scarpazza,Cristina Scarpazza,Rafael Garcia-Dias,Sandra Vieira,Lea Baecker,Pedro F. da Costa,Pedro F. da Costa,Alberto Redolfi,Giovanni B. Frisoni,Michela Pievani,Vince D. Calhoun,João Ricardo Sato,Andrea Mechelli +14 more
TL;DR: In this article, the authors used deep autoencoders to assess how individuals deviated from the healthy norm and established which brain regions were associated with this deviation. And they found that patients exhibited deviations according to the severity of their clinical condition.