L
Lea H. Gregersen
Researcher at Francis Crick Institute
Publications - 18
Citations - 7327
Lea H. Gregersen is an academic researcher from Francis Crick Institute. The author has contributed to research in topics: RNA polymerase II & Gene. The author has an hindex of 13, co-authored 16 publications receiving 5641 citations. Previous affiliations of Lea H. Gregersen include Max Planck Society & University of Copenhagen.
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Circular RNAs are a large class of animal RNAs with regulatory potency
Sebastian Memczak,Marvin Jens,Antigoni Elefsinioti,Francesca Torti,Janna Krueger,Agnieszka Rybak,Luisa Maier,Sebastian D. Mackowiak,Lea H. Gregersen,Mathias Munschauer,Alexander Loewer,Ulrike Ziebold,Markus Landthaler,Christine Kocks,Ferdinand le Noble,Nikolaus Rajewsky +15 more
TL;DR: It is found that a human circRNA, antisense to the cerebellar degeneration-related protein 1 transcript (CDR1as), is densely bound by microRNA (miRNA) effector complexes and harbours 63 conserved binding sites for the ancient miRNA miR-7.
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Mechanisms and Evolution of Oxidative Sulfur Metabolism in Green Sulfur Bacteria
TL;DR: The last common ancestor of currently known GSB was probably photoautotrophic, hydrogenotrophic and contained SQR but not DSR or SOX, and the predominance of the Chlorobium–Chlorobaculum–Prosthecochloris lineage among cultured GSB could be due to the horizontally acquired DSR and SOX systems.
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MiR-203 controls proliferation, migration and invasive potential of prostate cancer cell lines.
Giuditta Viticchiè,Anna Maria Lena,Alessia Latina,Amanda Formosa,Lea H. Gregersen,Anders H. Lund,Sergio Bernardini,Alessandro Mauriello,Roberto Miano,Luigi Giusto Spagnoli,Richard A. Knight,E Candi,Gerry Melino +12 more
TL;DR: It is shown that miR-203 is downregulated in clinical primary prostatic tumors compared tonormal prostate tissue, and in metastatic prostate cancer cell lines compared to normal epithelial prostatic cells, and could be a potentially new prognostic marker and therapeutic target in metastatics prostate cancer.
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MOV10 Is a 5′ to 3′ RNA Helicase Contributing to UPF1 mRNA Target Degradation by Translocation along 3′ UTRs
Lea H. Gregersen,Markus Schueler,Mathias Munschauer,Guido Mastrobuoni,Wei Chen,Stefan Kempa,Christoph Dieterich,Markus Landthaler +7 more
TL;DR: It is demonstrated that MOV10 has an ATP-dependent 5' to 3' in vitro RNA unwinding activity and the RNA-binding sites of MOV10 and its helicase mutants are determined using PAR-CLIP, which reveals that MOV 10 and UPF1 bind to RNA in close proximity.
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MicroRNA-145 Targets YES and STAT1 in Colon Cancer Cells
TL;DR: The study identifies and validates new cancer-relevant direct targets of miR-145 in colon cancer cells and adds important mechanistic understanding of the tumor-suppressive functions of mi R-145.