Leah N Huiting

TL;DR: The advantages of in vivo imaging, large progeny, and rapid development that the zebrafish provides make it an attractive model to promote novel cancer drug discovery and reduce the hurdles and cost of clinical trials.

TL;DR: These studies identify UFD1 as a critical regulator of the ER stress response and a novel contributor to MyC-mediated leukemia aggressiveness, with implications for targeted therapy in T-ALL and likely other MYC-driven cancers.

TL;DR: CORE disruption is identified as an early and remediable cause of gentamicin proteotoxicity that precedes downstream UPR activation and cell death, and preserved the CORE significantly improves renal cell survival likely by reducing organelle-specific proteot toxicity during gentamicIn exposure.

TL;DR: This research seeks to understand how T acute lymphoblastic leukemia (T-ALL) escapes disruption of the tricarboxylic acid (TCA) cycle, a biochemical pathway critical for T-ALL survival, and shows that leukemic cells modify their DNA to increase the activity of other pathways to compensate for diminished TCA cycle function.

TL;DR: Current knowledge on how ERAD promotes protein degradation, regulates immune cell development and function, participates in antigen presentation, exerts paradoxical roles on tumorigenesis and immunity, and thus impacts current cancer therapy are summarized.