Z
Zhiyong Wang
Researcher at Boston Medical Center
Publications - 31
Citations - 1479
Zhiyong Wang is an academic researcher from Boston Medical Center. The author has contributed to research in topics: Medicine & Apoptosis. The author has an hindex of 16, co-authored 23 publications receiving 1293 citations. Previous affiliations of Zhiyong Wang include Boston University.
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Journal ArticleDOI
Hsp27 Inhibits Bax Activation and Apoptosis via a Phosphatidylinositol 3-Kinase-dependent Mechanism
Andrea Havasi,Zhijian Li,Zhiyong Wang,Jody L. Martin,Venugopal Botla,Kathleen L. Ruchalski,John H. Schwartz,Steven C. Borkan +7 more
TL;DR: Data show that Hsp27 antagonizes Bax-mediated mitochondrial injury and apoptosis by promoting Akt activation via a PI3-kinase-dependent mechanism.
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Rapamycin Ameliorates Proteinuria-Associated Tubulointerstitial Inflammation and Fibrosis in Experimental Membranous Nephropathy
Ramon G. Bonegio,Robert Fuhro,Zhiyong Wang,C. Robert Valeri,Chris Andry,David J. Salant,Wilfred Lieberthal +6 more
TL;DR: It is shown that rapamycin ameliorates the tubulointerstitial disease associated with chronic proteinuria and loss of renal mass and completely inhibited compensatory renal hypertrophy.
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Albumin is a major serum survival factor for renal tubular cells and macrophages through scavenging of ROS
Jose Iglesias,Vivian Elizabeth Abernethy,Zhiyong Wang,Wilfred Lieberthal,Jason S. Koh,Jerrold S. Levine +5 more
TL;DR: Delipidated BSA protected cells from apoptosis induced by FCS withdrawal at concentrations as low as 1% of that in FCS, implicate albumin as a major serum survival factor and inhibits apoptosis by scavenging reactive oxygen species (ROS).
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Lithium activates the Wnt and phosphatidylinositol 3-kinase Akt signaling pathways to promote cell survival in the absence of soluble survival factors
Diviya Sinha,Zhiyong Wang,Kathleen L. Ruchalski,Jerrold S. Levine,Selvi Krishnan,Wilfred Lieberthal,John H. Schwartz,Steven C. Borkan +7 more
TL;DR: The data suggest that Li(+) or BIO promotes renal epithelial cell survival by inhibiting apoptosis through GSK3beta-dependent activation of the Wnt pathway and subsequent release of IGF-II.
Journal ArticleDOI
Distinct hsp70 domains mediate apoptosis-inducing factor release and nuclear accumulation.
Kathleen L. Ruchalski,Haiping Mao,Zhijian Li,Zhiyong Wang,Sara Gillers,Yihan Wang,Dick D. Mosser,Vladimir L. Gabai,John H. Schwartz,Steen C Borkan +9 more
TL;DR: It is demonstrated that mitochondrial protection against bax-mediated injury requires both intact chaperone and ATPase functions, whereas the ATPase domain is critical for sequestering leaked AIF in the cytosol.