Hui Feng

TL;DR: It is proposed that CUL-4 prevents aberrant re-initiation of DNA replication, at least in part, by facilitating the degradation of CDT-1, which is required for DNA replication in Caenorhabditis elegans.

TL;DR: Current knowledge about the fuels feeding the cycle, effects of oncogenes and tumor suppressors on fuel and cycle usage, common genetic alterations and deregulation of cycle enzymes, and potential therapeutic opportunities for targeting the TCA cycle in cancer cells are summarized.

TL;DR: A transgenic zebrafish model of neuroblastoma is generated in which MYCN-induced tumors arise from a subpopulation of neuroblasts that migrate into the adrenal medulla analog following organogenesis, and coexpression of activated ALK with MYCN in this model triples the disease penetrance and markedly accelerates tumor onset.

TL;DR: It is shown that leukemias from this transgenic line are highly penetrant and render animals moribund by 80.7 ± 17.6 days of life, providing an essential step in preparing this model for chemical and genetic screens designed to identify modifiers of Myc-induced T-ALL.

TL;DR: Blockade of intravasation and hematologic dissemination in T-LBL is due to elevated S1P1 signaling, increased expression of ICAM1, and augmented homotypic cell-cell adhesion.