L
Lean Beulen
Researcher at Radboud University Nijmegen
Publications - 12
Citations - 444
Lean Beulen is an academic researcher from Radboud University Nijmegen. The author has contributed to research in topics: Prenatal diagnosis & Trisomy. The author has an hindex of 9, co-authored 12 publications receiving 349 citations.
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Journal ArticleDOI
Trial by Dutch Laboratories for Evaluation of Non-Invasive Prenatal Testing. Part II - Women's Perspectives
Rachèl V. van Schendel,Godelieve C.M.L. Page-Christiaens,Lean Beulen,C. M. Bilardo,Marjon A. de Boer,A. Coumans,Brigitte H. W. Faas,Irene M. van Langen,Klaske D. Lichtenbelt,Merel C. van Maarle,Merryn V. E. Macville,Dick Oepkes,Eva Pajkrt,Lidewij Henneman +13 more
TL;DR: To evaluate preferences and decision‐making among high‐risk pregnant women offered a choice between Non‐Invasive Prenatal Testing (NIPT), invasive testing or no further testing.
Journal ArticleDOI
Origin and clinical relevance of chromosomal aberrations other than the common trisomies detected by genome-wide NIPS: Results of the TRIDENT study
Diane Van Opstal,Merel C. van Maarle,Klaske D. Lichtenbelt,Marjan M. Weiss,Heleen Schuring-Blom,Shama L. Bhola,Mariëtte J.V. Hoffer,Karin Huijsdens-van Amsterdam,Merryn V. E. Macville,Angelique J. A. Kooper,Brigitte H. W. Faas,Lutgarde C.P. Govaerts,Gita M. B. Tan-Sindhunata,Nicolette S. den Hollander,Ilse Feenstra,Robert-Jan H. Galjaard,Dick Oepkes,Stijn A. I. Ghesquiere,Rutger W W Brouwer,Lean Beulen,Sander Bollen,Martin G Elferink,Roy Straver,Lidewij Henneman,Godelieve C.M.L. Page-Christiaens,Erik A. Sistermans +25 more
TL;DR: Genome-wide NIPS in pregnancies at risk for trisomy 21, 18, or 13, reveals a chromosomal aberration other than trisome 21,18 or 13 in about one-third of the abnormal cases, which involves a fetal or placental chromosome aberration with clinical relevance for pregnancy management.
Journal ArticleDOI
The consequences of implementing non-invasive prenatal testing in Dutch national health care: a cost-effectiveness analysis.
Lean Beulen,Janneke P.C. Grutters,Brigitte H. W. Faas,Ilse Feenstra,John M. G. van Vugt,Mireille N. Bekker +5 more
TL;DR: Non-invasive prenatal testing using cell-free fetal DNA in maternal plasma has been developed for the detection of fetal aneuploidy and should be implemented in national health care as an optional secondary screening test for those pregnancies complicated by a high risk for T21.
Journal ArticleDOI
The effect of a decision aid on informed decision-making in the era of non-invasive prenatal testing: a randomised controlled trial.
Lean Beulen,Michelle van den Berg,Brigitte H. W. Faas,Ilse Feenstra,Michiel Hageman,John M. G. van Vugt,Mireille N. Bekker +6 more
TL;DR: This study shows that the implementation of a web-based multimedia decision aid directly facilitates the ultimate goal of prenatal testing for fetal chromosomal abnormalities, which is enabling informed autonomous reproductive choice.
Journal ArticleDOI
Clinical utility of non-invasive prenatal testing in pregnancies with ultrasound anomalies.
Lean Beulen,Brigitte H. W. Faas,Ilse Feenstra,J. M. G. van Vugt,Mireille N. Bekker,Mireille N. Bekker +5 more
TL;DR: To evaluate the application of non‐invasive prenatal testing (NIPT) as an alternative to invasive diagnostic prenatal testing in pregnancies with abnormal ultrasound findings.