L
Leanne Cartee
Researcher at GlaxoSmithKline
Publications - 3
Citations - 120
Leanne Cartee is an academic researcher from GlaxoSmithKline. The author has contributed to research in topics: Lapatinib & Cmax. The author has an hindex of 3, co-authored 3 publications receiving 96 citations. Previous affiliations of Leanne Cartee include Research Triangle Park.
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Journal ArticleDOI
A phase Ib dose-escalation study of the MEK inhibitor trametinib in combination with the PI3K/mTOR inhibitor GSK2126458 in patients with advanced solid tumors
Juneko E. Grilley-Olson,Philippe L. Bedard,Angelica Fasolo,Cornfeld Mark J,Cornfeld Mark J,Cornfeld Mark J,Leanne Cartee,Leanne Cartee,Albiruni Ryan Abdul Razak,Lee-Anne Stayner,Yuehui Wu,Yuehui Wu,R. Greenwood,R. Greenwood,R. Greenwood,Rajeshwar Singh,Rajeshwar Singh,Carrie B. Lee,Johanna C. Bendell,H. A. Burris,G. Del Conte,Cristiana Sessa,J. R. Infante +22 more
TL;DR: GSK458 plus trametinib is poorly tolerated, due to skin and GI-related toxicities, which may be due to overlapping toxicities precluding sufficient dose exposure.
Journal ArticleDOI
Effects of low-fat and high-fat meals on steady-state pharmacokinetics of lapatinib in patients with advanced solid tumours.
Lot A. Devriese,Kevin M. Koch,Marja Mergui-Roelvink,Gemma M. Matthys,Wen Wee Ma,André Robidoux,Joe Stephenson,Quincy Chu,Keith W. Orford,Leanne Cartee,Jeff Botbyl,Nikita Arya,Jan H.M. Schellens,Jan H.M. Schellens +13 more
TL;DR: Both low-fat and high-fat food consumed 1 h before lapatinib administration increased Lapatinib systemic exposure compared with lapatinIB administration 1 H before a low- fat meal, and it is advised to administer the drug 1 h before a meal.
Journal ArticleDOI
Effects of Esomeprazole on the Pharmacokinetics of Lapatinib in Breast Cancer Patients.
Kevin M. Koch,Young-Hyuck Im,Sung Bae Kim,Ander Urruticoechea Ribate,Joe Stephenson,Jeffrey Botbyl,Leanne Cartee,Jane Holshouser,Derry Ridgway +8 more
TL;DR: Esomeprazole treatment resulted in decreased lapatinib bioavailability that was inversely associated with patient age as a significant covariate.