Lee E. Eiden

TL;DR: The Connections Map for PC12 Cell Differentiation brings into focus the complex array of specific cellular responses that rely on canonical signal transduction systems.

TL;DR: The nucleotide sequence of a complete cDNA copy of enkephalin precursor mRNA from human phaeochromocytoma is reported and shows that the precursor is 267 amino acids long and contains six interspersed Met-enkephaline sequences and one Leu-encephalin sequence.

TL;DR: The combined use of morphological and biochemical methods provided evidence for a partially overlapping distribution and possible interaction between an ascending brainstem and descending telencephalic cholecystokinin fiber systems within the striatum and related rostral forebrain areas.

TL;DR: Direct comparison of serotonin uptake indicated that serotonin was the preferred substrate, and the characteristics of [3H]serotonin accumulation by CV-1 cells expressing the cDNA clone suggested sequestration by an intracellular compartment.

TL;DR: Two isoforms of the human vesicular monoamine transporter (hVMAT1 and hVMAT2) provide new markers for multiple neuroendocrine lineages, and examination of their transport properties provides mechanistic insights into the pharmacology and physiology of amine storage in cardiovascular, endocrine, and central nervous system function.