Lee K. Opresko

TL;DR: The ability to use multiplex library screening demonstrates the usefulness of this approach for high-throughput antibody isolation for proteomics applications.

TL;DR: The data suggest that overexpression of erbB-2 inhibits both its down-regulation and that of the EGFR, and the net effect is increased signaling through the EGfr system.

TL;DR: Results indicate that soluble rather than membrane-anchored forms of the ligands mediate most of the biological effects of EGFR ligands, which have shown promise in preventing spread of metastatic disease.

TL;DR: The characterization of single‐cell ERK dynamics provides a quantitative foundation for understanding the regulatory structure of this signaling cascade and revealed that negative feedback from phosphorylated ERK to the cascade input was necessary to match the robustness of the oscillation characteristics observed over a broad range of ligand concentrations.

TL;DR: A quantitative method to evaluate the interaction between cell surface receptors and the endocytic apparatus is developed and it is found that constitutive internalization of the transferrin receptor behaves as a simple, first order process that is unaltered by ligand.