Nikki Bollinger

TL;DR: The characterization of single‐cell ERK dynamics provides a quantitative foundation for understanding the regulatory structure of this signaling cascade and revealed that negative feedback from phosphorylated ERK to the cascade input was necessary to match the robustness of the oscillation characteristics observed over a broad range of ligand concentrations.

TL;DR: It is demonstrated that within a single cell type, the EG FR autocrine system can couple multiple signaling pathways to ERK activation and that this modulation of EGFR autocrine signaling can be accomplished at multiple regulatory steps.

TL;DR: ProMAT generates a set of comprehensive figures for assessing results and diagnosing process quality from enzyme-linked immunosorbent assay microarray experiments, and is distributed as open-source Java and R code.

TL;DR: The results identify ERK1/2 activation as a mediator of LPA‐stimulated MC3T3‐E1 cell migration that may be relevant to preosteoblast motility and gene expression during bone repair in vivo.

TL;DR: A conceptual overview of the different approaches for protein microarray is provided, and some of the most significant applications of these microarrays to date are examined, with an emphasis on how global protein analyses can be used to facilitate biomedical research.