Haluk Resat

TL;DR: This review provides a full spectrum of STAT3's involvement in breast cancers by consolidating the knowledge about its role in breast cancer development at multiple levels: its differential regulation by different receptor signaling pathways, its downstream target genes, and modification of its transcriptional activity by its coregulatory transcription factors.

TL;DR: The characterization of single‐cell ERK dynamics provides a quantitative foundation for understanding the regulatory structure of this signaling cascade and revealed that negative feedback from phosphorylated ERK to the cascade input was necessary to match the robustness of the oscillation characteristics observed over a broad range of ligand concentrations.

TL;DR: An integrated model of both the trafficking and signaling pathway of the epidermal growth factor receptor (EGFR) using a probability weighted-dynamic Monte Carlo simulation is presented, suggesting that receptor trafficking controls the compartmental bias of signal transduction, rather than simply modulating signal magnitude.

TL;DR: In this article, the dynamic solvation time correlation function Z(t) is formulated in terms of the intermolecular solute-solvent interactions, without recourse to the intrinsically macroscopic concept of a cavity carved out of a dielectric medium.

TL;DR: Simulation data revealed that the sterol type has noticeable effect on the properties of AmB membrane channels, and observed differences suggest that the channel in the ergosterol-containing membrane is more stable and, due to its larger size, would have a higher ion conductance.