L
Leen J M Seys
Researcher at Ghent University Hospital
Publications - 16
Citations - 801
Leen J M Seys is an academic researcher from Ghent University Hospital. The author has contributed to research in topics: COPD & Inflammation. The author has an hindex of 11, co-authored 15 publications receiving 564 citations. Previous affiliations of Leen J M Seys include Ghent University.
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Journal ArticleDOI
MicroRNA Profiling Reveals a Role for MicroRNA-218-5p in the Pathogenesis of Chronic Obstructive Pulmonary Disease
Griet Conickx,Pieter Mestdagh,Francisco Avila Cobos,Fien M. Verhamme,Tania Maes,Bart M. Vanaudenaerde,Leen J M Seys,Lies Lahousse,Richard Kim,Alan Hsu,Peter A. B. Wark,Peter A. B. Wark,Philip M. Hansbro,Guy Joos,Jo Vandesompele,Ken R. Bracke,Guy Brusselle +16 more
TL;DR: In vitro and in vivo perturbation of miR‐218‐5p combined with RNA sequencing and gene set enrichment analysis was used to elucidate its functional role in COPD pathogenesis and highlight a role for miR-218‐ 5p in the pathogenesis of COPD.
Journal ArticleDOI
Role of B Cell–Activating Factor in Chronic Obstructive Pulmonary Disease
Leen J M Seys,Fien M. Verhamme,Anja Schinwald,Hamida Hammad,Danen Cunoosamy,Claudie Bantsimba-Malanda,Alan Sabirsh,Eileen McCall,Liz Flavell,Ronald Herbst,Sharen Provoost,Bart N. Lambrecht,Guy Joos,Guy Brusselle,Ken R. Bracke +14 more
TL;DR: B cell-activating factor expression was significantly increased in lungs of patients with COPD and CS-exposed mice and is present around both immune and stromal cells within lymphoid follicles.
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Role of CXCL13 in Cigarette Smoke–induced Lymphoid Follicle Formation and Chronic Obstructive Pulmonary Disease
Ken R. Bracke,Fien Verhamme,Leen J M Seys,Claudie Bantsimba-Malanda,Danen Cunoosamy,Ronald Herbst,Hamida Hammad,Bart N. Lambrecht,Guy Joos,Guy Brusselle +9 more
TL;DR: In this paper, the role of B cell-attracting chemokine CXCL13 in the formation of tertiary lymphoid organs (TLOs) was investigated in the lungs of patients with severe chronic obstructive pulmonary disease (COPD).
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DPP4, the Middle East Respiratory Syndrome Coronavirus Receptor, is Upregulated in Lungs of Smokers and Chronic Obstructive Pulmonary Disease Patients
Leen J M Seys,W. Widagdo,Fien Verhamme,Alex KleinJan,Wim Janssens,Guy Joos,Ken R. Bracke,Bart L. Haagmans,Guy Brusselle +8 more
TL;DR: The MERS coronavirus receptor, dipeptidyl peptidase 4 is upregulated in the lungs of smokers and chronic obstructive pulmonary disease (COPD) patients, which offers a potential mechanism for the increased susceptibility of smoker and COPD patients for MERS-CoV infection.
Journal ArticleDOI
B cells in chronic obstructive pulmonary disease: moving to center stage
TL;DR: The evidence that links B cells and B cell-rich lymphoid follicles to the pathogenesis of COPD and the mechanisms involved is outlined and the potential and limitations of B cells as therapeutic targets to slow the progression of human COPD are reviewed.