G
Griet Conickx
Researcher at Ghent University Hospital
Publications - 8
Citations - 374
Griet Conickx is an academic researcher from Ghent University Hospital. The author has contributed to research in topics: COPD & microRNA. The author has an hindex of 5, co-authored 8 publications receiving 279 citations. Previous affiliations of Griet Conickx include Ablynx.
Papers
More filters
Journal ArticleDOI
Asthma inflammatory phenotypes show differential microRNA expression in sputum
Tania Maes,Francisco Avila Cobos,Florence Schleich,Valentina Sorbello,Monique Henket,Katleen De Preter,Ken R. Bracke,Griet Conickx,Claire Mesnil,Jo Vandesompele,Lies Lahousse,Fabrice Bureau,Pieter Mestdagh,Guy Joos,Fabio Luigi Massimo Ricciardolo,Guy Brusselle,Renaud Louis +16 more
TL;DR: Expression of miR-629-3p, mi-223-3P, and mi-142-3 p is increased in sputum of patients with severe asthma and is linked to neutrophilic airway inflammation, suggesting that these miRNAs contribute to this asthma inflammatory phenotype.
Journal ArticleDOI
MicroRNA Profiling Reveals a Role for MicroRNA-218-5p in the Pathogenesis of Chronic Obstructive Pulmonary Disease
Griet Conickx,Pieter Mestdagh,Francisco Avila Cobos,Fien M. Verhamme,Tania Maes,Bart M. Vanaudenaerde,Leen J M Seys,Lies Lahousse,Richard Kim,Alan Hsu,Peter A. B. Wark,Peter A. B. Wark,Philip M. Hansbro,Guy Joos,Jo Vandesompele,Ken R. Bracke,Guy Brusselle +16 more
TL;DR: In vitro and in vivo perturbation of miR‐218‐5p combined with RNA sequencing and gene set enrichment analysis was used to elucidate its functional role in COPD pathogenesis and highlight a role for miR-218‐ 5p in the pathogenesis of COPD.
Journal ArticleDOI
microRNA profiling in lung tissue and bronchoalveolar lavage of cigarette smoke-exposed mice and in COPD patients: a translational approach.
Griet Conickx,Francisco Avila Cobos,Maarten van den Berge,Alen Faiz,Wim Timens,Pieter S. Hiemstra,Guy Joos,Guy Brusselle,Pieter Mestdagh,Ken R. Bracke +9 more
TL;DR: Investigating miRNA profiling data in different compartments and both species provided accumulating insights in miRNAs that may be relevant in CS-induced inflammation and the pathogenesis of COPD.
Journal ArticleDOI
A microRNA-21-mediated SATB1/S100A9/NF-κB axis promotes chronic obstructive pulmonary disease pathogenesis
Richard Kim,Richard Kim,Krishna P. Sunkara,Krishna P. Sunkara,Krishna P. Sunkara,Ken R. Bracke,Andrew G. Jarnicki,Chantal Donovan,Chantal Donovan,Alan Hsu,Antonio Ieni,Emma L. Beckett,Izabela Galvão,Sara R.A. Wijnant,Fabio Lm Ricciardolo,Antonino Di Stefano,Tatt Jhong Haw,Gang Liu,Angela Ferguson,Angela Ferguson,Umamainthan Palendira,Peter A. B. Wark,Griet Conickx,Griet Conickx,Pieter Mestdagh,Guy Brusselle,Gaetano Caramori,Paul S. Foster,Jay C. Horvat,Philip M. Hansbro,Philip M. Hansbro +30 more
TL;DR: Chronic obstructive pulmonary disease (COPD) is the third leading cause of morbidity and death worldwide as mentioned in this paper and inhalation of cigarette smoke is the major cause in developed countries.
Journal ArticleDOI
Airway Surface Dehydration Aggravates Cigarette Smoke-Induced Hallmarks of COPD in Mice.
Leen J M Seys,Fien M. Verhamme,Lisa L. Dupont,Elke Desauter,Julia Duerr,Ayça Seyhan Agircan,Griet Conickx,Guy Joos,Guy Brusselle,Marcus A. Mall,Ken R. Bracke +10 more
TL;DR: It is concluded that airway surface dehydration is a risk factor that aggravates CS-induced hallmarks of COPD and accelerated the formation of pulmonary lymphoid follicles in βENaC-Tg mice.