Alan Hsu

TL;DR: In vitro and in vivo perturbation of miR‐218‐5p combined with RNA sequencing and gene set enrichment analysis was used to elucidate its functional role in COPD pathogenesis and highlight a role for miR-218‐ 5p in the pathogenesis of COPD.

TL;DR: In this paper, the authors found that Fbln1c was increased in COPD patients and in cigarette smoke-induced (CS-induced) experimental COPD in mice, which occurred through disrupted collagen organization and interactions with fibronectin, periostin, and tenascin-c.

TL;DR: It is found that IAV infections lead to increased inflammatory and antiviral responses in primary bronchial epithelial cells (pBECs) from healthy nonsmoking and smoking subjects and in patients with chronic obstructive pulmonary disease, and miR-125a or -b and A20 may be targeted therapeutically to inhibit excessive inflammatory responses and enhance antiviral immunity in IAV infection and in COPD.

TL;DR: Recent trends in various novel drug delivery carriers including microparticles, microemulsions, microspheres, nanoparticles, liposomes, dendrimers, solid lipid nanocarriers etc which can help in combating the oxidative stress in CRDs and ultimately reducing the disease burden and improving the quality of life with CRDs patients are highlighted.

TL;DR: It was found that there was constitutive release of IFN-β by BECs and this was critical in inducing late antiviral signaling via type I IFN receptors, and was crucial in limiting viral infection.