L
Lei Feng
Researcher at Fourth Military Medical University
Publications - 14
Citations - 434
Lei Feng is an academic researcher from Fourth Military Medical University. The author has contributed to research in topics: Notch signaling pathway & Cellular differentiation. The author has an hindex of 9, co-authored 14 publications receiving 396 citations.
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Journal ArticleDOI
Notch activation promotes cell proliferation and the formation of neural stem cell-like colonies in human glioma cells
Xueping Zhang,Gang Zheng,Lian Zou,Hui-Ling Liu,Li-Hong Hou,Peng Zhou,Dan-Dan Yin,Qi-Jun Zheng,Liang Liang,Su-Zhen Zhang,Lei Feng,Libo Yao,Angang Yang,Hua Han,Jingyuan Chen +14 more
TL;DR: Notch signaling promote the formation of cancer stem cell-like cells in human glioma, suggesting that Notch signaling play roles in cancer stem cells and cancer cells with a stem cell phenotype.
Journal ArticleDOI
Notch signaling regulates the FOXP3 promoter through RBP-J- and Hes1-dependent mechanisms
Hai-Feng Ou-Yang,Hong-Wei Zhang,Chang-Gui Wu,Ping Zhang,Jian Zhang,Junchang Li,Li-Hong Hou,Fei He,Xin-Yu Ti,Liqiang Song,Su-Zhen Zhang,Lei Feng,Hao-Wen Qi,Hua Han +13 more
TL;DR: Evidence is provided that Notch signaling can modulate the FOXP3 promoter through RBP-J- and Hes1-dependent mechanisms and it is shown that the Notch intracellular domain (NIC), the active form of Notch receptors, activates a reporter driven by the Foxp3 promoter.
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Notch signaling inhibits growth of the human lung adenocarcinoma cell line A549.
Qi-Jun Zheng,Hong-Yan Qin,Hongwei Zhang,Jun-Chang Li,Li-Hong Hou,Hongbin Wang,Xueping Zhang,Su-Zhen Zhang,Lei Feng,Ying-Min Liang,Hua Han,Dinghua Yi +11 more
TL;DR: The results suggest that the Notch signaling may function as a tumor inhibitor in human lung adenocarcinoma cells.
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Transcription factor RBP-J-mediated signaling represses the differentiation of neural stem cells into intermediate neural progenitors.
Fang Gao,Qi Zhang,Min-Hua Zheng,Hui-Ling Liu,Yi-Yang Hu,Ping Zhang,Zheng-Ping Zhang,Hong-Yan Qin,Lei Feng,Li Wang,Hua Han,Gong Ju +11 more
TL;DR: Results indicated that the RBP-J-mediated signaling might inhibit the differentiation of NSCs into INPs and support the generation of certain early born neurons at early neurogenic stages.
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The PcG protein HPC2 inhibits RBP-J-mediated transcription by interacting with LIM protein KyoT2.
TL;DR: KyoT2 might inhibit the RBP‐J‐mediated transactivation through NIC by recruiting co‐suppressors such as HPC2, which functions as a transcriptional suppressor.