J
Jingyuan Chen
Researcher at Fourth Military Medical University
Publications - 101
Citations - 2961
Jingyuan Chen is an academic researcher from Fourth Military Medical University. The author has contributed to research in topics: Neurotoxicity & Apoptosis. The author has an hindex of 30, co-authored 98 publications receiving 2490 citations. Previous affiliations of Jingyuan Chen include Columbia University & New York University.
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Journal ArticleDOI
Notch activation promotes cell proliferation and the formation of neural stem cell-like colonies in human glioma cells
Xueping Zhang,Gang Zheng,Lian Zou,Hui-Ling Liu,Li-Hong Hou,Peng Zhou,Dan-Dan Yin,Qi-Jun Zheng,Liang Liang,Su-Zhen Zhang,Lei Feng,Libo Yao,Angang Yang,Hua Han,Jingyuan Chen +14 more
TL;DR: Notch signaling promote the formation of cancer stem cell-like cells in human glioma, suggesting that Notch signaling play roles in cancer stem cells and cancer cells with a stem cell phenotype.
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Manganese induces dopaminergic neurodegeneration via microglial activation in a rat model of manganism
TL;DR: Results suggested that dopaminergic neurons could be damaged by manganese neurotoxicity, and that the activated microglial cells and their associated activation products played an important role in this neurodegenerative process.
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Differential cytotoxicity of Mn(II) and Mn(III): special reference to mitochondrial [Fe-S] containing enzymes.
TL;DR: In vitro results suggest that Mn(III) species appears to be more cytotoxic than Mn(II) species, possibly due to higher oxidative reactivity and closer radius resemblance to Fe.
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Iron supplement prevents lead-induced disruption of the blood-brain barrier during rat development
Qiang Wang,Wenjing Luo,Wei Zheng,Yiping Liu,Hui Xu,Gang Zheng,Zhongming Dai,Wenbin Zhang,Yaoming Chen,Jingyuan Chen +9 more
TL;DR: The data suggest that Pb exposure disrupts the structure of the BBB in young animals and iron (Fe) supplement may prevent against Pb-induced BBB disruption, and the increased BBB permeability may facilitate the accumulation of Pb.
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Involvement of Microglia Activation in the Lead Induced Long-Term Potentiation Impairment
Mingchao Liu,Xin-Qin Liu,Wen Wang,Xuefeng Shen,Honglei Che,Yan-Yan Guo,Ming-Gao Zhao,Jingyuan Chen,Wenjing Luo +8 more
TL;DR: Results showed that Pb can cause microglia activation, which can up-regulate the level of IL-1β, TNF-α and iNOS, these proinflammatory factors may cause hippocampal neuronal injury as well as LTP deficits.