G
Gang Zheng
Researcher at Fourth Military Medical University
Publications - 28
Citations - 1014
Gang Zheng is an academic researcher from Fourth Military Medical University. The author has contributed to research in topics: Morris water navigation task & Neurotoxicity. The author has an hindex of 16, co-authored 27 publications receiving 868 citations. Previous affiliations of Gang Zheng include Purdue University.
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Journal ArticleDOI
Notch activation promotes cell proliferation and the formation of neural stem cell-like colonies in human glioma cells
Xueping Zhang,Gang Zheng,Lian Zou,Hui-Ling Liu,Li-Hong Hou,Peng Zhou,Dan-Dan Yin,Qi-Jun Zheng,Liang Liang,Su-Zhen Zhang,Lei Feng,Libo Yao,Angang Yang,Hua Han,Jingyuan Chen +14 more
TL;DR: Notch signaling promote the formation of cancer stem cell-like cells in human glioma, suggesting that Notch signaling play roles in cancer stem cells and cancer cells with a stem cell phenotype.
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Manganese induces dopaminergic neurodegeneration via microglial activation in a rat model of manganism
TL;DR: Results suggested that dopaminergic neurons could be damaged by manganese neurotoxicity, and that the activated microglial cells and their associated activation products played an important role in this neurodegenerative process.
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Iron supplement prevents lead-induced disruption of the blood-brain barrier during rat development
Qiang Wang,Wenjing Luo,Wei Zheng,Yiping Liu,Hui Xu,Gang Zheng,Zhongming Dai,Wenbin Zhang,Yaoming Chen,Jingyuan Chen +9 more
TL;DR: The data suggest that Pb exposure disrupts the structure of the BBB in young animals and iron (Fe) supplement may prevent against Pb-induced BBB disruption, and the increased BBB permeability may facilitate the accumulation of Pb.
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Changes in the synaptic structure of hippocampal neurons and impairment of spatial memory in a rat model caused by chronic arsenite exposure.
Jinfei Jing,Gang Zheng,Mingchao Liu,Xuefeng Shen,Fang Zhao,Jiye Wang,Jianbin Zhang,Guanpeng Huang,Peng Dai,Yinglei Chen,Jingyuan Chen,Wenjing Luo +11 more
TL;DR: Together, chronic sodium arsenite exposure through drinking water results in detrimental changes in the neuronal synapses, which may contribute to the arsenite-induced impairment of spatial memory.
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Manganese induces the overexpression of α-synuclein in PC12 cells via ERK activation.
Tongjian Cai,Ting Yao,Gang Zheng,Yaoming Chen,Kejun Du,Yunxin Cao,Xuefeng Shen,Jingyuan Chen,Wenjing Luo +8 more
TL;DR: Manganese exposure induced the overexpression of α-synuclein via ERK1/2 activation, which may play a role in manganese-induced cytotoxicity, and the MEK1 inhibitor PD98059, which inhibits the activation of ERK MAPK, attenuated the overexpressions and the cytot toxicity induced by manganous.