Leila R de Mendonça

TL;DR: It is demonstrated that dengue-specific antibodies enhance the infection of a primary Brazilian ZIKV isolate in a FcγRII-expressing K562 cell line and that serum samples from d Dengue-immune pregnant women enhanced ZikV infection.

TL;DR: The data suggest that the CNS may be directly affected due to an unbalanced and chronic local inflammatory response, elicited by ZIKV infection, which contributes to damage to the fetal brain.

TL;DR: Evaluated for the first time, the thiopurine nucleoside analogue 6MMPr is identified as a promising antiviral candidate against ZIKV that warrants further in vivo evaluation.

TL;DR: iNOS−/− mice were more resistant to Rocio virus encephalitis, presenting a lower clinical score and reduced mortality rate, despite the increased tissue pathology, suggesting that nitric oxide overproduction might have an important role in the progression of experimental viral encephalopathy.